WFDC9
Protein WFDC9
Also known as: dJ688G8.2, WAP9, WFDC9_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NEX5
- Gene
- WFDC9
- Ensembl
- ENSG00000180205
- Chromosome
- 20
- Canonical length
- 89 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
The WAP-type four-disulfide core (WFDC) domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many members of the WFDC domain family. This gene encodes a protein which contains a WFDC domain, and is thus a member of the WFDC domain family. This gene and several other gene family members are clustered at 20q13.12. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
89 residues, UniProt reviewed canonical sequence.
>Q8NEX5|WFDC9
1 MKPWILLLVM FISGVVMLLP VLGSFWNKDP FLDMIRETEQ CWVQPPYKYC EKRCTKIMTC
61 VRPNHTCCWT YCGNICLDNE EPLKSMLNPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against WFDC9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 933 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 933 nTPM
- seminal vesicle: 2 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- epididymal principal cells: 1,412 nCPM
- epididymal clear cells: 14 nCPM
- epididymal basal cells: 13 nCPM
- epicardial cells: 4.5 nCPM
- mesothelial cells: 4.3 nCPM
- mast cells: 3.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.3 nTPM
- hippocampal formation: 0.2 nTPM
- basal ganglia: 0.1 nTPM
- hypothalamus: 0.1 nTPM
- medulla oblongata: 0.1 nTPM
- pons: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.76
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.35
- DepMap mean gene effect
- -0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads WFDC9 as an antibody target. Whether an autoantibody or antibody against WFDC9 could matter depends on whether native WFDC9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
WFDC9 is annotated as secreted, so native WFDC9 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label WFDC9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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