WFDC3
WAP four-disulfide core domain protein 3
Also known as: dJ447F3.3, WAP14, WFDC3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IUB2
- Gene
- WFDC3
- Ensembl
- ENSG00000124116
- Chromosome
- 20
- Canonical length
- 231 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains four WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Alternatively spliced transcript variants have been observed but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
231 residues, UniProt reviewed canonical sequence.
>Q8IUB2|WFDC3
1 MMLSCLFLLK ALLALGSLES WITAGEHAKE GECPPHKNPC KELCQGDELC PAEQKCCTTG
61 CGRICRDIPK GRKRDCPRVI RKQSCLKRCI TDETCPGVKK CCTLGCNKSC VVPISKQKLA
121 EFGGECPADP LPCEELCDGD ASCPQGHKCC STGCGRTCLG DIEGGRGGDC PKVLVGLCIV
181 GCVMDENCQA GEKCCKSGCG RFCVPPVLPP KLTMNPNWTV RSDSELEIPV PLocalizationUniProt · AlphaFold · HPA
Whether an antibody against WFDC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 19 nTPM
Expression across tissuesHPA
Tissue
- testis: 19 nTPM
- skin: 16 nTPM
- breast: 1.2 nTPM
- choroid plexus: 1.1 nTPM
- smooth muscle: 0.8 nTPM
- epididymis: 0.7 nTPM
Single-cell type
- late spermatids: 351 nCPM
- late primary spermatocytes: 289 nCPM
- rod photoreceptor cells: 131 nCPM
- early spermatids: 98 nCPM
- early primary spermatocytes: 57 nCPM
- salivary ionocytes: 56 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- midbrain: 1.4 nTPM
- spinal cord: 1.1 nTPM
- medulla oblongata: 0.9 nTPM
- pons: 0.8 nTPM
- thalamus: 0.8 nTPM
- white matter: 0.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.59
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.41
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads WFDC3 as an antibody target. Whether an autoantibody or antibody against WFDC3 could matter depends on whether native WFDC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
WFDC3 is annotated as secreted, so native WFDC3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label WFDC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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