Seroatlas · Human Serome Atlas

WFDC13

WAP four-disulfide core domain protein 13

Also known as: C20orf138, dJ601O1.3, WAP13, WFD13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IUB5
Gene: WFDC13
Ensembl: ENSG00000168634
Chromosome: 20
Canonical length: 93 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

93 residues, UniProt reviewed canonical sequence.

>Q8IUB5|WFDC13
     1  MKPVLPLQFL VVFCLALQLV PGSPKQRVLK YILEPPPCIS APENCTHLCT MQEDCEKGFQ
    61  CCSSFCGIVC SSETFQKRNR IKHKGSEVIM PAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WFDC13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 85 nTPM

Expression across tissuesHPA

Tissue

epididymis: 85 nTPM
retina: 2 nTPM
urinary bladder: 0.3 nTPM
seminal vesicle: 0.2 nTPM
cerebral cortex: 0.1 nTPM
lung: 0.1 nTPM

Single-cell type

epididymal principal cells: 117 nCPM
rod photoreceptor cells: 26 nCPM
oocytes: 4.6 nCPM
cone photoreceptor cells: 4.1 nCPM
epididymal basal cells: 2.9 nCPM
retinal amacrine cells: 2.1 nCPM

Immune cell

naive CD4 T-cell: 0.6 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

medulla oblongata: 0.7 nTPM
midbrain: 0.7 nTPM
spinal cord: 0.4 nTPM
white matter: 0.4 nTPM
cerebral cortex: 0.3 nTPM
hypothalamus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0.02
gnomAD missense Z: 0.27
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

serine-type endopeptidase inhibitor activity

Cellular components

extracellular space

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WFDC13 as an antibody target. Whether an autoantibody or antibody against WFDC13 could matter depends on whether native WFDC13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WFDC13 is annotated as secreted, so native WFDC13 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label WFDC13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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