WFDC12
WAP four-disulfide core domain protein 12
Also known as: C20orf122, dJ211D12.4, WAP2, WFD12_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WWY7
- Gene
- WFDC12
- Ensembl
- ENSG00000168703
- Chromosome
- 20
- Canonical length
- 111 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
111 residues, UniProt reviewed canonical sequence.
>Q8WWY7|WFDC12
1 MGSSSFLVLM VSLVLVTLVA VEGVKEGIEK AGVCPADNVR CFKSDPPQCH TDQDCLGERK
61 CCYLHCGFKC VIPVKELEEG GNKDEDVSRP YPEPGWEAKC PGSSSTRCPQ KLocalizationUniProt · AlphaFold · HPA
Whether an antibody against WFDC12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 40 nTPM
Expression across tissuesHPA
Tissue
- skin: 40 nTPM
- vagina: 8.6 nTPM
- esophagus: 6.7 nTPM
- cervix: 6.6 nTPM
- seminal vesicle: 2.8 nTPM
- breast: 2.4 nTPM
Single-cell type
- esophageal apical cells: 28 nCPM
- alveolar cells type 2: 8 nCPM
- alveolar cells type 1: 3.8 nCPM
- transitional alveolar cells: 3.1 nCPM
- breast secretory cells: 1.5 nCPM
- gastric progenitor cells: 1.3 nCPM
Immune cell
- MAIT T-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- basal ganglia: 11 nTPM
- hippocampal formation: 10 nTPM
- cerebral cortex: 10 nTPM
- thalamus: 9.8 nTPM
- pons: 9.5 nTPM
- amygdala: 9.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.72
- gnomAD pLI
- 0.04
- gnomAD missense Z
- -0.17
- DepMap mean gene effect
- 0
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads WFDC12 as an antibody target. Whether an autoantibody or antibody against WFDC12 could matter depends on whether native WFDC12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
WFDC12 is annotated as secreted, so native WFDC12 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label WFDC12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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