WFDC11
Protein WFDC11
Also known as: WAP11, WFD11_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NEX6
- Gene
- WFDC11
- Ensembl
- ENSG00000180083
- Chromosome
- 20
- Canonical length
- 87 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
87 residues, UniProt reviewed canonical sequence.
>Q8NEX6|WFDC11
1 MVSLMKLWIP MLMTFFCTVL LSVLGEMRKK RYDRKELLLE ECWGKPNVKE CTNKCSKAFR
61 CKDKNYTCCW TYCGNICWIN VETSGDYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against WFDC11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 89 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 89 nTPM
- testis: 4.7 nTPM
- bone marrow: 2.8 nTPM
- retina: 1.8 nTPM
- skin: 1.5 nTPM
- salivary gland: 0.6 nTPM
Single-cell type
- epididymal principal cells: 165 nCPM
- early spermatids: 97 nCPM
- late spermatids: 5.1 nCPM
- mesothelial cells: 4.1 nCPM
- late primary spermatocytes: 3.5 nCPM
- rod photoreceptor cells: 2.6 nCPM
Immune cell
- basophil: 2.3 nTPM
- neutrophil: 0.3 nTPM
- NK-cell: 0.3 nTPM
- naive B-cell: 0.2 nTPM
- naive CD8 T-cell: 0.2 nTPM
- plasmacytoid DC: 0.2 nTPM
Brain region
- cerebellum: 23 nTPM
- white matter: 23 nTPM
- cerebral cortex: 22 nTPM
- hypothalamus: 18 nTPM
- pons: 18 nTPM
- amygdala: 17 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.71
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.52
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads WFDC11 as an antibody target. Whether an autoantibody or antibody against WFDC11 could matter depends on whether native WFDC11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
WFDC11 is annotated as secreted, so native WFDC11 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label WFDC11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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