WFDC10B
Protein WFDC10B
Also known as: WAP12, WF10B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IUB3
- Gene
- WFDC10B
- Ensembl
- ENSG00000182931
- Chromosome
- 20
- Canonical length
- 73 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Vesicles
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript variants have been found for this gene, and they encode distinct isoforms. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
73 residues, UniProt reviewed canonical sequence.
>Q8IUB3|WFDC10B
1 MAPQTLLLVL VLCVLLLQAQ GGYRDKMRMQ RIKVCEKRPS IDLCIHHCSY FQKCETNKIC
61 CSAFCGNICM SILLocalizationUniProt · AlphaFold · HPA
Whether an antibody against WFDC10B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 26 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 26 nTPM
- retina: 11 nTPM
- urinary bladder: 4.7 nTPM
- testis: 4.2 nTPM
- skin: 1.1 nTPM
- prostate: 0.8 nTPM
Single-cell type
- rod photoreceptor cells: 203 nCPM
- epididymal principal cells: 76 nCPM
- ependymal cells: 31 nCPM
- salivary ionocytes: 23 nCPM
- late primary spermatocytes: 17 nCPM
- late spermatids: 16 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 1.1 nTPM
- midbrain: 1 nTPM
- medulla oblongata: 0.8 nTPM
- spinal cord: 0.7 nTPM
- white matter: 0.5 nTPM
- pons: 0.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.79
- gnomAD pLI
- 0.04
- gnomAD missense Z
- 0.16
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads WFDC10B as an antibody target. Whether an autoantibody or antibody against WFDC10B could matter depends on whether native WFDC10B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
WFDC10B is annotated as secreted, so native WFDC10B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label WFDC10B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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