WFDC10A
WAP four-disulfide core domain protein 10A
Also known as: C20orf146, dJ688G8.3, WAP10, WF10A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H1F0
- Gene
- WFDC10A
- Ensembl
- ENSG00000180305
- Chromosome
- 20
- Canonical length
- 79 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
79 residues, UniProt reviewed canonical sequence.
>Q9H1F0|WFDC10A
1 MAPQTLLPVL VLCVLLLQAQ GGYRDKKRMQ KTQLSPEIKV CQQQPKLYLC KHLCESHRDC
61 QANNICCSTY CGNVCMSILLocalizationUniProt · AlphaFold · HPA
Whether an antibody against WFDC10A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 271 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 271 nTPM
- seminal vesicle: 0.6 nTPM
- cerebral cortex: 0.2 nTPM
- stomach: 0.1 nTPM
- testis: 0.1 nTPM
- adipose tissue: 0 nTPM
Single-cell type
- epididymal principal cells: 492 nCPM
- epididymal basal cells: 5.9 nCPM
- oocytes: 4.6 nCPM
- epididymal clear cells: 4.1 nCPM
- late spermatids: 3.7 nCPM
- epididymal efferent duct ciliated cells: 2.5 nCPM
Immune cell
- naive CD4 T-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebral cortex: 0.5 nTPM
- medulla oblongata: 0.2 nTPM
- white matter: 0.2 nTPM
- basal ganglia: 0.1 nTPM
- hippocampal formation: 0.1 nTPM
- pons: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.94
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.05
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads WFDC10A as an antibody target. Whether an autoantibody or antibody against WFDC10A could matter depends on whether native WFDC10A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
WFDC10A is annotated as secreted, so native WFDC10A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label WFDC10A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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