Seroatlas · Human Serome Atlas

WFDC1

WAP four-disulfide core domain protein 1

Also known as: PS20, WFDC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HC57
Gene
WFDC1
Ensembl
ENSG00000103175
Chromosome
16
Canonical length
220 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

220 residues, UniProt reviewed canonical sequence.

>Q9HC57|WFDC1
     1  MPLTGVGPGS CRRQIIRALC LLLLLLHAGS AKNIWKRALP ARLAEKSRAE EAGAPGGPRQ
    61  PRADRCPPPP RTLPPGACQA ARCQADSECP RHRRCCYNGC AYACLEAVPP PPVLDWLVQP
   121  KPRWLGGNGW LLDGPEEVLQ AEACSTTEDG AEPLLCPSGY ECHILSPGDV AEGIPNRGQC
   181  VKQRRQADGR ILRHKLYKEY PEGDSKNVAE PGRGQQKHFQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WFDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
108 nTPM

Expression across tissuesHPA

Tissue

  • seminal vesicle: 108 nTPM
  • blood vessel: 105 nTPM
  • placenta: 94 nTPM
  • colon: 84 nTPM
  • prostate: 73 nTPM
  • urinary bladder: 53 nTPM

Single-cell type

  • peritubular myoid cells: 272 nCPM
  • hepatic stellate cells: 232 nCPM
  • platelets: 214 nCPM
  • retinal bipolar cells: 179 nCPM
  • megakaryocytes: 173 nCPM
  • vascular smooth muscle cells: 158 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 14 nTPM
  • cerebral cortex: 9.6 nTPM
  • medulla oblongata: 9.6 nTPM
  • amygdala: 8.9 nTPM
  • basal ganglia: 8.6 nTPM
  • hypothalamus: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.72
gnomAD pLI
0
gnomAD missense Z
-1.71
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WFDC1 as an antibody target. Whether an autoantibody or antibody against WFDC1 could matter depends on whether native WFDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WFDC1 is annotated as secreted, so native WFDC1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label WFDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WFDC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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