Seroatlas · Human Serome Atlas

WDR97

WD repeat-containing protein 97

Also known as: KIAA1875, WDR97_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NE52
Gene
WDR97
Ensembl
ENSG00000179698
Chromosome
8
Canonical length
1622 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

The function and protein-coding potential of this gene is unknown. The exon combination is based on AB058778.1 for which two possible open reading frames can be predicted (with start codons at nucleotide 26 or 2614). The position of the first ORF stop codon is consistent with a prediction of nonsense-mediated decay. Given the observation of the first ORF and its length, a predicted translation of the second ORF is inconsistent with the translation leaky scanning theory. Therefore, this gene is represented as a non-protein-coding transcript. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

1622 residues, UniProt reviewed canonical sequence.

>A6NE52|WDR97
     1  MEAEVWEAEG YNLVLDSDLY DADGYDVPDP GLLTEKNELT FTEPSQVLPF LTSSQQWQSL
    61  TPRARARRLW LLLRTSLHEV VEKEKRAELR AARLTHGLEP LRRLEVAAGL RSVAQDPVGG
   121  RFVVLDGAGR LHLHKEDGWA QETLLAPVRL TGLVTVLGPL GAVGRFVGWG PAGLAILRPN
   181  LSLLWLSEQG VGRAPGWAPT CCLPVPDLRL LLVAEMNSSL ALWQFRSGGR RLVLRGSALH
   241  PPPSPTGRLM RLAVAPVPPH HVLRCFAAYG SAVLTFDLHA WTLVDVRRDL HKTTISDLAY
   301  CEEVEAMVTA SRDSTVKVWE ADWQIRMVFV GHTGPVTAMT VLPNTTLVLS ASQDGTLRTW
   361  DLQAAAQVGE VALGFWGQDK LSRRVGRLLA PVRPGWPVLS LCASSMQLWR VRELYSPLAQ
   421  LPAKVLHVQV APALPAPAHQ SLPTRLVCAC ADGSVYLLSA ATGRIVSSLL LEPEDCAAAV
   481  AYCLPREALW LLTRAGHLVR ANAARCPMSV LHRVCPPPPP APQPCCLHLY SHLTDLEGAF
   541  SSWEIVRQHW GELRCSSVAC AWKNKNRYLP VVGHTDGTLS VLEWLSSKTV FQTEAHSPGP
   601  VVAIASTWNS IVSSGGDLTV KMWRVFPYAE ESLSLLRTFS CCYPAVALCA LGRRVTAGFE
   661  DPDSATYGLV QFGLGDSPRL DHRPQDDPTD HITGLCCCPT LKLYACSSLD CTVRIWTAEN
   721  RLLRLLQLNG APQALAFCSN SGDLVLALGS RLCLVSHRLY LPTSYLVKKM CRKAPDVVDD
   781  PPLPLMSQES LTSAQLQRLT NLHGAASLSE ALSLIHRRRA TSQHLVPKED LDAIVARDRD
   841  LQQLRLGLVV PAAQPPPSWQ QRQEGFDNYL RLIYGSGLLG MQSGRGSQQW SAGTLRVERE
   901  TRDVCAVPQA AHCLARAEVS TAAQTVPTAL SPQDLGALGQ HFSQSPRVTV PIPPTHRRVH
   961  SKASQLLARS SLSHYLGISL DLQLQLEQLR GRTTMALDLP SSHLQCRIPL LPKRWDKEPL
  1021  SSLRGFFPAT VQPHKHCLRP ICFPGYVPNS AVLQQMWLNA EPGASQDALW LWRPRPSQTQ
  1081  WQRKLLQWMG EKPGEEGEED KKEEEEEKED EELDWALASL SPHSNQQLDS WELEDQSAVD
  1141  WTQEPRRRSC KVARTHPHPW HRHGSLLLDE HYGHLPKFLH FFIYQTWFKK LFPIFSLQAY
  1201  PEAGTIEGLA SLLVALLEKT TWVDRVHILQ VLLRLLPNMS SDLQGQLQGL LVHLLNLDQP
  1261  PSLQDQTQKK FVILALQLLL ACSLESRDVV LELMSYFLYS PVHCRPELKK LLHGLGLQDP
  1321  EGFLFKEMMT WVQGPDLDSK AGLRTCCHQK LEDMIQELQE TPSQTSVVSG APTRASVIPS
  1381  GTSWSASGIF GRLSQVSEVP LMVVSPAEPH SLAPELQAQR MLAPKRSWGT PQLRLRVLSE
  1441  TLKSFCLEPE ARLHPAGPAQ LPGEPPPLEE TDWSHSQLLD LGPIDALNFF CEQLRAQQRS
  1501  SLQEKAAHPH PPEPYTVAPV PDMVVPPPRE HWYHPILRLQ EAKPQRSARS AMRLRGPMRS
  1561  RLCAGRTLDG PIRTLKLPLP RVEPQPFPLD WPMPPRPLPP RLLQPALQRY FLPADADPDT
  1621  YS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR97 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
1.4 nTPM

Expression across tissuesHPA

Tissue

  • testis: 1.4 nTPM
  • cerebellum: 0.3 nTPM
  • retina: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • choroid plexus: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM

Single-cell type

  • paneth cells: 12 nCPM
  • choroid plexus epithelial cells: 11 nCPM
  • brain excitatory neurons: 11 nCPM
  • brain inhibitory neurons: 9.3 nCPM
  • late primary spermatocytes: 7.1 nCPM
  • cone photoreceptor cells: 6.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.4 nTPM
  • medulla oblongata: 0.4 nTPM
  • basal ganglia: 0.2 nTPM
  • hypothalamus: 0.2 nTPM
  • midbrain: 0.2 nTPM
  • white matter: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR97 as an antibody target. Whether an autoantibody or antibody against WDR97 could matter depends on whether native WDR97 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR97 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR97 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR97. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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