WDR93

Protein identityUniProt · HPA

UniProt accession

Q6P2C0

Gene

WDR93

Ensembl

ENSG00000140527

Chromosome

15

Canonical length

686 aa

Protein class

Predicted intracellular proteins

Subcellular location

Actin filaments

OverviewNCBI Gene

Predicted to be involved in electron transport chain. Predicted to be part of respiratory chain complex I. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

686 residues, UniProt reviewed canonical sequence.

>Q6P2C0|WDR93
     1  MSFPRGSQTQ KIKHPIGTRK GPLEVPPPTE KDWPKDDEQD HVLVDPDEEL DSLPQPYRMI
    61  NKLVNLLFDQ SWEIIEERNA LREAESSQIQ PTVYPPLGEI QLNKMPNCMA VSQDYVFIGG
   121  AKGFSIYNLY SAKQIYAWEK LKVDVTSIWA TDLGNEILIA PVDEMGIIRL FYFYKEGLYL
   181  VKAINEVDDT SKQTTCIKME ISQGGDFAAF LLQGAGDIWL DVYKLPKETW LKKLEHPQLT
   241  SNPKKKVRQP QLNSLGPISA DPLEMDANVS FKGDIKLSLP VYIMKIKPPK PVTGTTFKSP
   301  LEVFAKIKDC YGLGSGQNHF IKDSQWEQQA EIFNASYKKY LDREWEEEPL STATFYFLLP
   361  SCLFAMPPEV KGPSGMACVL GIHWTRSHNF FLYSLNRTLK DKADPEGVWP CAAPIAVSQL
   421  SCSSSYLVLA CEDGVLTLWD LAKGFPLGVA ALPQGCFCQS IHFLKYFSVH KGQNMYPEGQ
   481  VKSQMKCVVL CTDASLHLVE ASGTQGPTIS VLVERPVKHL DKTICAVAPV PALPGMVLIF
   541  SKNGSVCLMD VAKREIICAF APPGAFPLEV PWKPVFAVSP DHPCFLLRGD YSHETASTDD
   601  AGIQYSVFYF NFEACPLLEN ISKNCTIPQR DLDNMAFPQA LPLEKRCERF LQKSYRKLEK
   661  NPEKEEEHWA RLQRYSLSLQ RENFKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR93 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

11 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDR93.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 104 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Autistic spectrum disorder with isolated skills

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.07

gnomAD pLI

0

gnomAD missense Z

0.21

DepMap mean gene effect

0

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• electron transport chain

Cellular components

• respiratory chain complex I

Protein domainsUniProt · Pfam · InterPro

• NADH dehydrogenase ubiquinone Fe-S protein 4 mitochondrial-like
• WD40/YVTN repeat-like-containing domain superfamily
• WD40-repeat-containing domain superfamily
• WD repeat-containing protein 93 beta-propeller
• WD repeat-containing protein 93

KeywordsUniProt

• WD repeat