Seroatlas · Human Serome Atlas

WDR89

WD repeat-containing protein 89

Also known as: C14orf150, MGC9907, WDR89_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96FK6
Gene: WDR89
Ensembl: ENSG00000140006
Chromosome: 14
Canonical length: 387 aa
Protein class: Predicted intracellular proteins
Subcellular location: Intermediate filaments,Cytosol

OverviewNCBI Gene

Predicted to act upstream of or within corpus callosum development and ventricular system development. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>Q96FK6|WDR89
     1  MEKIEEQFAN LHIVKCSLGT KEPTYLLGID TSKTVQAGKE NLVAVLCSNG SIRIYDKERL
    61  NVLREFSGYP GLLNGVRFAN SCDSVYSACT DGTVKCWDAR VAREKPVQLF KGYPSNIFIS
   121  FDINCNDHII CAGTEKVDDD ALLVFWDARM NSQNLSTTKD SLGAYSETHS DDVTQVRFHP
   181  SNPNMVVSGS SDGLVNVFDI NIDNEEDALV TTCNSISSVS CIGWSGKGYK QIYCMTHDEG
   241  FYWWDLNHLD TDEPVTRLNI QDVREVVNMK EDALDYLIGG LYHEKTDTLH VIGGTNKGRI
   301  HLMNCSMSGL THVTSLQGGH AATVRSFCWN VQDDSLLTGG EDAQLLLWKP GAIEKTFTKK
   361  ESMKIASSVH QRVRVHSNDS YKRRKKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR89 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

lymph node: 11 nTPM
retina: 11 nTPM
tonsil: 9.6 nTPM
thymus: 9.4 nTPM
thyroid gland: 8.6 nTPM
kidney: 8.2 nTPM

Single-cell type

megakaryocyte-erythroid progenitors: 40 nCPM
renal connecting tubule cells: 39 nCPM
myonuclei: 32 nCPM
distal convoluted tubule cells: 32 nCPM
renal collecting duct principal cells: 32 nCPM
rod photoreceptor cells: 30 nCPM

Immune cell

naive CD4 T-cell: 14 nTPM
naive CD8 T-cell: 12 nTPM
MAIT T-cell: 11 nTPM
T-reg: 10 nTPM
NK-cell: 9.4 nTPM
memory CD4 T-cell: 8.8 nTPM

Brain region

cerebellum: 20 nTPM
white matter: 16 nTPM
hypothalamus: 15 nTPM
cerebral cortex: 15 nTPM
basal ganglia: 15 nTPM
medulla oblongata: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 0.88
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
WD repeat-containing protein 89

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR89 as an antibody target. Whether an autoantibody or antibody against WDR89 could matter depends on whether native WDR89 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR89 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR89 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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