Seroatlas · Human Serome Atlas

WDR87

WD repeat-containing protein 87

Also known as: NYD-SP11, WDR87_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZQQ6
Gene: WDR87
Ensembl: ENSG00000171804
Chromosome: 19
Canonical length: 2873 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for WDR87 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

2873 residues, UniProt reviewed canonical sequence.

>Q6ZQQ6|WDR87
     1  MSSPRLIPLW KDLKLLLNDT INKSKQPSED PKNCLIVLSD RSQAVAWMKS KTEDMVEKRT
    61  FSMTERLPPI QSMVHAGSFH ILVVYCGDLI LRLFGDHFRA FKPLGKVPCR FNISCLCYDP
   121  EMKMLLSGIL GAVVTWVIEL GGTGLQIAHM VSMPGDELVQ DIVLNGPSGS LLALCETVVR
   181  VLMHQGKGQL GEVKRFTSTS SGSSITCCFT CFDQGFLYAG NQAGEIQVWS LQQGHPLHSF
   241  QAHQSGVICI RSRPEAHTLL TAGSDSLIKE WNLTSGSLLR RLELGEELYR LQFIDSITFF
   301  CQTAHSFSLH RLPCFYSLFN VCGSAPQQLR RVCCGNNWFR ILCTTEDGLL RFVSPVTGDL
   361  LVITWPFSIL DQAVDWAYDP GKEELFVATG SSEVLVFDTT RCPCPAKYLL GTSPNSQDFV
   421  QCLAYGHFNL GRGLEGLIFS GHQSGVIRVL SQHSCARLEK FMHFGAVLAL STLSGGIFGG
   481  QGNSLLCSYG MDDYVHLSEA VLDGVKVQLR PLASILSSCH LTHLILLPKS VGAITETNCL
   541  RLWKFHDFLS SGSQNGLKFI ETLPLHLCAI TSFDVCLSLS LFVTGSADGS VRIWDFHGRL
   601  IGILDSSLHF GPVCFANDRG DLLVTFNQSL YLVSCLKLLP PALLTRLSFM SISDEVLEVP
   661  KPFIPSFFFS FETMFVPKYI YPGQAQQKLV GLEKLVNNRA IAFDHSVPHV IEEDEEGSPV
   721  LLRSSMHYSL QDMEDWMQVS KRYQCHYVLP PQLQLTSWDG LNPYQILRYY FGHGREWLFA
   781  PDCYIPNSVI RARLWPEGTP IYLQCNLHAP QRELEWDRSQ EFFFWHSRVR AISNTEYPKN
   841  KEEDEHFLEM RLSKDVTYSV LTDGANRSWL GRKMSEITIN SMIETMLNIM VHASLLKYQC
   901  CVGALGQIFA SYQVSPALRS ETARRLLNDT TNSNPLIREL AWEGLKRLGM ITHLFAMPLA
   961  QGLMDKDERV RIKTLSLMAE IGIHSRTSLL QLTQKQETFR EMQQQMIGEE PLDHLLGMRA
  1021  TDLQILSTQV EQRLNENLTL SHRDEKPAFS LDVSMPSELK SSLKPPTVSE ESEVAIKPSK
  1081  GQRRGQAGVK KHSQKWLRGL KKTKERDSKQ MSTEPGLLED ESGTEAAPIE MEEASVYSQW
  1141  SSSTSVIKLS KDVDSQEKDI SKDHIALTLK RLQKIRDKRD KKATAQKLKK KHKKKGKEAK
  1201  VINEETTPPV MEQPVTKKVK IQGRGASGIS GRRSTAGDGS SWRDDLCRLM ALRISGSQTK
  1261  MSENLNAELV TFAQEMLVDR HPSWELFQEI CPLLKKESKV LLEDLDWDVV PPEKKPIFIQ
  1321  EGAIREDMIQ GVTQEVIRHK EVMPREEEQA QKKARDMLGL EETQVILKKG KKVIFLEPGN
  1381  VTMGKEISKK EEKKTFQKSP KQGRKAVQKE RKVGKIKREM TKEERDMSEE VEEMATLEEK
  1441  VVKQEGKLVM IERTPSWQDW KKAWDEWKQV HGETRKSWKA WKEEWEKRLL QEEEKLHQAG
  1501  EKLSPEEEML QEDKKLKWEE WKQVWENMLS SKSKEQQYKD EEEVTLEEEV SREGEEKEQQ
  1561  VTEEQRHIQE EHKWARIHRK RARAEKKRAQ EERKLAQEEE KLAQEERQLA QEERKLAQAY
  1621  VKITQDDREM AQAEGKFAQK EETLAQRGEK LSQEAEKLAQ KRKKLAKKWE KVAREEEKLA
  1681  KKGGKLAEVK NILAQKVEEL PQREQNLDWQ EKELAQELEE LEWDMEELSW KEEELNQEEG
  1741  KLVEEKKKLA EEEEALAWQR EKLSEEETKL AQEEELLIQE KEKLAQHKEK MPEEEERLGR
  1801  KREQLIEKKM KLAQKRERWI NSMEELTKNK MILYQKKNLA QEKKNLAQEK EKLAQRKENL
  1861  LYNKERLTHS KKQLVQVKNK LGMFNKILAQ VEEKLTQEKE TVIKKKEKLA ETEKKLVQVE
  1921  DSLAKKQEKL AQEKMKLALE KAMVQGKKRL RGELDIAKEE KALNLEMKRL AEEKMRLVEG
  1981  KETLSKGETP ETSRQRKMTQ VEQELFERKL SLEEKILLHE DRILAMEESE IAKGKLEFTR
  2041  GQRIFVQGQR KLAKASRKLI KKRESLSKEP AKLNKILKAL QKLTRDERKL TQEEIKMTKM
  2101  KRALFVKERR LSIEQSKLDI KEWDFSEKRS ELTKDEKKLA RKQRKLANKM RRMINKEEKM
  2161  TEEESKLARK HSEVILDDEE EGGIEEEEVI PFLKRRWRKR KEAKRGDKPK EKFSSQVDEV
  2221  ESEEHFSEEM ESLLDELEKQ ESLSSEEEEE REEEEEREEE EEREEEEERK EEEEGEEKQV
  2281  EKEEEEKKKK KKEKKKEEVQ EKEEVFEEKE EIMSEEETES LSDEEEEEES CSLEEEVDRE
  2341  KEILKKEKQF KLQEQRRKSL RGRERVLSIL RGVPHGKGRA IRLGVLKSPL KKLMSTALEM
  2401  KEKTPVPVPE KQISWEDKKA TVVEIPRKFL GTMDKEREVM GKYEPIPPHV LGTVLESQAQ
  2461  DLKTPFMSHI LRRTVEAEEL QHKPLGAWWK WFLQHPPLMG QTEVQLPLSQ IPAKEQHADV
  2521  SLSDVEWIRH VLERMEAGEQ LSRDGFHRLC QLLKDLASKG NLEWLHLAKH EAIVYRHRQA
  2581  LESQDTRISS RQSMSPKYLK VIPPIKAKEK ESWPKPLAVP TQKSPLATKR IPDPRAKNWH
  2641  LLGEPYRSER AQQISIAHKE MEMQYFYPAT RDIFPSAHAS VEKQTLALMF QKDFWDFKDK
  2701  RRFPKLPKLE KKTQPISKKK EELPLWETFV ALYHVLRMLQ QRYPKDSTAW MEQFYQLMDL
  2761  YQLKSPRIQK LLQELLMREE PQPQEIIYEE ALKATELVPG ERLFCCLFCG SSHTPRSPQE
  2821  FQGAVPLPWQ NCVRTILPVG IARYGILELA WKSLPEADLH LTKALTHTVA PTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR87 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

testis: 16 nTPM
thyroid gland: 0.3 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late primary spermatocytes: 147 nCPM
early primary spermatocytes: 44 nCPM
early spermatids: 22 nCPM
late spermatids: 13 nCPM
differentiating spermatogonia: 7.5 nCPM
undifferentiated spermatogonia: 2.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.4 nTPM
pons: 0.4 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.3 nTPM
cerebral cortex: 0.3 nTPM
hippocampal formation: 0.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDR87.

Disease | ImmuneIEDB

Conditions an epitope on WDR87 was assayed in.

colon adenocarcinoma T cell
brain glioblastoma multiforme T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0
gnomAD missense Z: 4.22
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR87 as an antibody target. Whether an autoantibody or antibody against WDR87 could matter depends on whether native WDR87 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR87 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR87 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...