WDR83OS

Protein identityUniProt · HPA

UniProt accession

Q9Y284

Gene

WDR83OS

Ensembl

ENSG00000105583

Chromosome

19

Canonical length

106 aa

Protein class

Predicted membrane proteins, Transporters

Subcellular location

Endoplasmic reticulum

OverviewNCBI Gene

Enables protein folding chaperone. Involved in multi-pass transmembrane protein insertion into ER membrane. Located in endoplasmic reticulum membrane. Part of multi-pass translocon complex and protein folding chaperone complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

106 residues, UniProt reviewed canonical sequence.

>Q9Y284|WDR83OS
     1  MSTNNMSDPR RPNKVLRYKP PPSECNPALD DPTPDYMNLL GMIFSMCGLM LKLKWCAWVA
    61  VYCSFISFAN SRSSEDTKQM MSSFMLSISA VVMSYLQNPQ PMTPPW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR83OS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

3

Mean surface accessibility (rSASA)

0.52

Highest tissue expression

261 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDR83OS.

Disease | AllUniProt

Conditions WDR83OS is implicated in, by any mechanism.

• Neurodevelopmental disorder with variable familial hypercholanemia (NEDFHCA) MIM:621016

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 33 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Hypercholanemia, familial
• Neurodevelopmental disorder with variable familial hypercholanemia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.65

gnomAD pLI

0

gnomAD missense Z

0.7

DepMap mean gene effect

-0.15

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• multi-pass transmembrane protein insertion into ER membrane
• protein insertion into ER membrane

Molecular functions

• protein folding chaperone

Cellular components

• endoplasmic reticulum membrane
• multi-pass translocon complex
• protein folding chaperone complex

Protein domainsUniProt · Pfam · InterPro

• PAT complex subunit Asterix
• PAT complex subunit Asterix

KeywordsUniProt

• Acetylation
• Chaperone
• Endoplasmic reticulum
• Intellectual disability
• Membrane
• Transmembrane
• Transmembrane helix