WDR70
WD repeat-containing protein 70
Also known as: FLJ10233, WDR70_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NW82
- Gene
- WDR70
- Ensembl
- ENSG00000082068
- Chromosome
- 5
- Canonical length
- 654 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Mitochondria,Cytosol
OverviewNCBI Gene
Enables enzyme binding activity. Predicted to be located in nucleoplasm. Predicted to be active in nucleus and site of double-strand break. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
654 residues, UniProt reviewed canonical sequence.
>Q9NW82|WDR70
1 MERSGPSEVT GSDASGPDPQ LAVTMGFTGF GKKARTFDLE AMFEQTRRTA VERSRKTLEA
61 REKEEEMNRE KELRRQNEDI EPTSSRSNVV RDCSKSSSRD TSSSESEQSS DSSDDELIGP
121 PLPPKMVGKP VNFMEEDILG PLPPPLNEEE EEAEEEEEEE EEEENPVHKI PDSHEITLKH
181 GTKTVSALGL DPSGARLVTG GYDYDVKFWD FAGMDASFKA FRSLQPCECH QIKSLQYSNT
241 GDMILVVSGS SQAKVIDRDG FEVMECIKGD QYIVDMANTK GHTAMLHTGS WHPKIKGEFM
301 TCSNDATVRT WEVENPKKQK SVFKPRTMQG KKVIPTTCTY SRDGNLIAAA CQNGSIQIWD
361 RNLTVHPKFH YKQAHDSGTD TSCVTFSYDG NVLASRGGDD SLKLWDIRQF NKPLFSASGL
421 PTMFPMTDCC FSPDDKLIVT GTSIQRGCGS GKLVFFERRT FQRVYEIDIT DASVVRCLWH
481 PKLNQIMVGT GNGLAKVYYD PNKSQRGAKL CVVKTQRKAK QAETLTQDYI ITPHALPMFR
541 EPRQRSTRKQ LEKDRLDPLK SHKPEPPVAG PGRGGRVGTH GGTLSSYIVK NIALDKTDDS
601 NPREAILRHA KAAEDSPYWV SPAYSKTQPK TMFAQVESDD EEAKNEPEWK KRKILocalizationUniProt · AlphaFold · HPA
Whether an antibody against WDR70 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 15 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 15 nTPM
- bone marrow: 12 nTPM
- ovary: 12 nTPM
- thymus: 11 nTPM
- endometrium: 11 nTPM
- blood vessel: 10 nTPM
Single-cell type
- microglia: 393 nCPM
- myonuclei: 378 nCPM
- thymic myoid cells: 374 nCPM
- neutrophil progenitors: 287 nCPM
- distal convoluted tubule cells: 282 nCPM
- renal connecting tubule cells: 265 nCPM
Immune cell
- intermediate monocyte: 21 nTPM
- non-classical monocyte: 20 nTPM
- plasmacytoid DC: 19 nTPM
- myeloid DC: 18 nTPM
- classical monocyte: 17 nTPM
- eosinophil: 15 nTPM
Brain region
- cerebellum: 26 nTPM
- white matter: 23 nTPM
- medulla oblongata: 20 nTPM
- pons: 20 nTPM
- thalamus: 20 nTPM
- choroid plexus: 19 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.76
- gnomAD pLI
- 0
- gnomAD missense Z
- 2.21
- DepMap mean gene effect
- -1.37
- DepMap dependency class
- pan
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads WDR70 as an antibody target. Whether an autoantibody or antibody against WDR70 could matter depends on whether native WDR70 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
WDR70 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label WDR70 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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