Seroatlas · Human Serome Atlas

WDR64

WD repeat-containing protein 64

Also known as: FLJ32978, WDR64_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
B1ANS9
Gene
WDR64
Ensembl
ENSG00000162843
Chromosome
1
Canonical length
1081 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for WDR64 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1081 residues, UniProt reviewed canonical sequence.

>B1ANS9|WDR64
     1  MDIRKEKRLN MALQMSNFKK ALNRFEKLVE QTAAQKRDER AGLFIHKEDA IGYDKFYASV
    61  QKLFGPDVKN QDVKRFYRKL CNNTDASADW CEIFGYFSSE EDPIASQLDE ENLVFFVSRK
   121  RRILISGSRR RDVIKSIVKI PHLDLLITAT QKGLITVFNN QDTSWITGCD YLLQLKRIVA
   181  TTERTIIVWD YKAQGSSQEN YFVIKPMDHC LLCVCVVPLP DHLCRDDILL GDDGGFVNRF
   241  TVNSDDFGIK QAKSKRKLQN QVLDSKNFKS VKRKLHNDWV MKIRYISALN CFGSCSLDSN
   301  HSLVLESLKR LEDNLPVREF SMPRGANTFC YCVKANVIVT GGDDKVIRLW HPNISTKPVG
   361  KLVGHMFSIA EIVTNEKDQH VVSLSSAKVF RVWDIQTLSL LQVFHDSQGG PGDMQIYSMI
   421  YDANHGMLIT GSSVMDMYPL TRMIQDTKQV PHTHEREINV MLYNKYFHQV LTICSESIIR
   481  VWELETGLQV YQILEPHGFN TEVTSAAVDE SGFLFATGAY NGTVRIWDFG SGQEMKVLPE
   541  GKDWKEDEHC LRRLIFLKAQ EKHQQLVLAL ERNGTIKMIQ GKEDDIYLMV IWELPDVVPF
   601  LQDGKHAVHL RMSTRDRNMA IPFPDVELIV ERNFSQPTDN PTMDLLRVNC IDLLQVEGYN
   661  LIAAGTLNGV IILWNFVTST VKKVYRPEDC FTVNPDLHPK HFKINDILFL FRTPECARRS
   721  SQDSICSSSQ CESSKGPQSS KGSKQSIHDS EVKGEQTDVM VGKQQPMDKK HPGIANLPEA
   781  QPPILVTAHE DGHLRLWTLE GRLLKDMLPF TKHSAISLTS LYTDSCTRIL LAGNVEGHVI
   841  LCNISSFLDP PHDEKKFKQL LSWRAHSLEI IQVIYVEEKQ VVLTASIDGS VRLWHALNGH
   901  YCGYFGQRRL FELSQTRDFI LPCDVTEYPI EIKEESKFTE KQKYEYPLIF DREKWRKMSS
   961  VSLLFKRTPP KAFEVEQDFK FFKSLSSPKI RRYPLEGFVT ENREAGIVFG SLPIYSISSP
  1021  TSLRFLPLIG VEAQKDSSDG ITGKKKGGHV QREKAPRRRS LKKNLVPQIN LASSFFPAIP
  1081  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR64 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
0.8 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.8 nTPM
  • placenta: 0.2 nTPM
  • adrenal gland: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • colon: 0.1 nTPM
  • duodenum: 0.1 nTPM

Single-cell type

  • early spermatids: 349 nCPM
  • late spermatids: 241 nCPM
  • undifferentiated spermatogonia: 29 nCPM
  • late primary spermatocytes: 22 nCPM
  • plasma cells: 15 nCPM
  • early primary spermatocytes: 15 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM
  • midbrain: 0.2 nTPM
  • white matter: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.09
gnomAD pLI
0
gnomAD missense Z
0.86

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR64 as an antibody target. Whether an autoantibody or antibody against WDR64 could matter depends on whether native WDR64 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR64 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR64 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR64. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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