Seroatlas · Human Serome Atlas

WDR55

WD repeat-containing protein 55

Also known as: FLJ20195, FLJ21702, WDR55_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H6Y2
Gene: WDR55
Ensembl: ENSG00000120314
Chromosome: 5
Canonical length: 383 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to be involved in rRNA processing. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

383 residues, UniProt reviewed canonical sequence.

>Q9H6Y2|WDR55
     1  MDRTCEERPA EDGSDEEDPD SMEAPTRIRD TPEDIVLEAP ASGLAFHPAR DLLAAGDVDG
    61  DVFVFSYSCQ EGETKELWSS GHHLKACRAV AFSEDGQKLI TVSKDKAIHV LDVEQGQLER
   121  RVSKAHGAPI NSLLLVDENV LATGDDTGGI CLWDQRKEGP LMDMRQHEEY IADMALDPAK
   181  KLLLTASGDG CLGIFNIKRR RFELLSEPQS GDLTSVTLMK WGKKVACGSS EGTIYLFNWN
   241  GFGATSDRFA LRAESIDCMV PVTESLLCTG STDGVIRAVN ILPNRVVGSV GQHTGEPVEE
   301  LALSHCGRFL ASSGHDQRLK FWDMAQLRAV VVDDYRRRKK KGGPLRALSS KTWSTDDFFA
   361  GLREEGEDSM AQEEKEETGD DSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR55 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

esophagus: 14 nTPM
spleen: 13 nTPM
bone marrow: 13 nTPM
liver: 13 nTPM
pancreas: 11 nTPM
small intestine: 11 nTPM

Single-cell type

esophageal apical cells: 76 nCPM
extravillous trophoblasts: 52 nCPM
esophageal suprabasal cells: 39 nCPM
breast lactating cells: 36 nCPM
esophageal basal cells: 35 nCPM
early spermatids: 34 nCPM

Immune cell

intermediate monocyte: 16 nTPM
non-classical monocyte: 14 nTPM
T-reg: 12 nTPM
MAIT T-cell: 11 nTPM
gdT-cell: 11 nTPM
memory CD4 T-cell: 10 nTPM

Brain region

choroid plexus: 15 nTPM
medulla oblongata: 14 nTPM
cerebellum: 13 nTPM
cerebral cortex: 13 nTPM
pons: 13 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: 0.97
DepMap mean gene effect: -1.22
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

rRNA processing

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40 repeat, conserved site
WD40-repeat-containing domain superfamily
WD repeat-containing protein 55/POC1
WD repeat-containing protein 55
WDR55

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR55 as an antibody target. Whether an autoantibody or antibody against WDR55 could matter depends on whether native WDR55 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR55 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR55 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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