Seroatlas · Human Serome Atlas

WDR54

WD repeat-containing protein 54

Also known as: FLJ12953, WDR54_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H977
Gene
WDR54
Ensembl
ENSG00000005448
Chromosome
2
Canonical length
334 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles,Primary cilium tip,Centriolar satellite,Acrosome,Flagellar centriole,Mid piece,Principal piece
Quaternary structure
Homotrimer

OverviewNCBI Gene

Enables protein homodimerization activity. Involved in negative regulation of receptor internalization; regulation of MAPK cascade; and regulation of epidermal growth factor receptor signaling pathway. Located in vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>Q9H977|WDR54
     1  MFRWERSIPL RGSAAALCNN LSVLQLPARN LTYFGVVHGP SAQLLSAAPE GVPLAQRQLH
    61  AKEGAGVSPP LITQVHWCVL PFRVLLVLTS HRGIQMYESN GYTMVYWHAL DSGDASPVQA
   121  VFARGIAASG HFICVGTWSG RVLVFDIPAK GPNIVLSEEL AGHQMPITDI ATEPAQGQDC
   181  VADMVTADDS GLLCVWRSGP EFTLLTRIPG FGVPCPSVQL WQGIIAAGYG NGQVHLYEAT
   241  TGNLHVQINA HARAICALDL ASEVGKLLSA GEDTFVHIWK LSRNPESGYI EVEHCHGECV
   301  ADTQLCGARF CDSSGNSFAV TGYDLAEIRR FSSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR54 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
66 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 66 nTPM
  • choroid plexus: 43 nTPM
  • testis: 37 nTPM
  • parathyroid gland: 28 nTPM
  • retina: 26 nTPM
  • pituitary gland: 24 nTPM

Single-cell type

  • fallopian tube ciliated cells: 497 nCPM
  • respiratory ciliated cells: 452 nCPM
  • epididymal efferent duct ciliated cells: 263 nCPM
  • endometrial ciliated cells: 213 nCPM
  • late primary spermatocytes: 195 nCPM
  • late spermatids: 189 nCPM

Immune cell

  • plasmacytoid DC: 47 nTPM
  • T-reg: 37 nTPM
  • memory CD4 T-cell: 36 nTPM
  • memory CD8 T-cell: 34 nTPM
  • MAIT T-cell: 32 nTPM
  • gdT-cell: 31 nTPM

Brain region

  • choroid plexus: 25 nTPM
  • hypothalamus: 17 nTPM
  • midbrain: 13 nTPM
  • cerebral cortex: 11 nTPM
  • medulla oblongata: 10 nTPM
  • basal ganglia: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.31
gnomAD pLI
0
gnomAD missense Z
0.44
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR54 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR54 as an antibody target. Whether an autoantibody or antibody against WDR54 could matter depends on whether native WDR54 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR54 is annotated at the cell surface, where native WDR54 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label WDR54 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR54. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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