Seroatlas · Human Serome Atlas

WDR53

WD repeat-containing protein 53

Also known as: MGC12928, MGC64882, WDR53_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5U6
Gene: WDR53
Ensembl: ENSG00000185798
Chromosome: 3
Canonical length: 358 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a protein containing WD domains. The function of this gene is unknown. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

358 residues, UniProt reviewed canonical sequence.

>Q7Z5U6|WDR53
     1  MAVKWTGGHS SPVLCLNASK EGLLASGAEG GDLTAWGEDG TPLGHTRFQG ADDVTSVLFS
    61  PSCPTKLYAS HGETISVLDV RSLKDSLDHF HVNEEEINCL SLNQTENLLA SADDSGAIKI
   121  LDLENKKVIR SLKRHSNICS SVAFRPQRPQ SLVSCGLDMQ VMLWSLQKAR PLWITNLQED
   181  ETEEMEGPQS PGQLLNPALA HSISVASCGN IFSCGAEDGK VRIFRVMGVK CEQELGFKGH
   241  TSGVSQVCFL PESYLLLTGG NDGKITLWDA NSEVEKKQKS PTKRTHRKKP KRGTCTKQGG
   301  NTNASVTDEE EHGNILPKLN IEHGEKVNWL LGTKIKGHQN ILVADQTSCI SVYPLNEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR53 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

testis: 70 nTPM
bone marrow: 14 nTPM
skeletal muscle: 12 nTPM
tongue: 12 nTPM
thymus: 11 nTPM
skin: 11 nTPM

Single-cell type

late primary spermatocytes: 389 nCPM
early spermatids: 299 nCPM
late spermatids: 147 nCPM
early primary spermatocytes: 42 nCPM
differentiating spermatogonia: 25 nCPM
oocytes: 23 nCPM

Immune cell

T-reg: 17 nTPM
eosinophil: 16 nTPM
MAIT T-cell: 14 nTPM
basophil: 13 nTPM
memory CD4 T-cell: 12 nTPM
naive CD4 T-cell: 10 nTPM

Brain region

pons: 12 nTPM
white matter: 11 nTPM
basal ganglia: 9.6 nTPM
cerebellum: 9.6 nTPM
cerebral cortex: 9 nTPM
hypothalamus: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.38
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR53 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DDB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR53 as an antibody target. Whether an autoantibody or antibody against WDR53 could matter depends on whether native WDR53 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR53 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR53 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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