Seroatlas · Human Serome Atlas

WDR47

WD repeat-containing protein 47

Also known as: KIAA0893, WDR47_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94967
Gene: WDR47
Ensembl: ENSG00000085433
Chromosome: 1
Canonical length: 919 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Actin filaments,Primary cilium

OverviewNCBI Gene

Predicted to act upstream of or within several processes, including detection of hot stimulus involved in thermoception; neuronal stem cell population maintenance; and telencephalon development. Predicted to be located in several cellular components, including growth cone; microtubule; and neuronal cell body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

919 residues, UniProt reviewed canonical sequence.

>O94967|WDR47
     1  MTAEETVNVK EVEIIKLILD FLNSKKLHIS MLALEKESGV INGLFSDDML FLRQLILDGQ
    61  WDEVLQFIQP LECMEKFDKK RFRYIILKQK FLEALCVNNA MSAEDEPQHL EFTMQEAVQC
   121  LHALEEYCPS KDDYSKLCLL LTLPRLTNHA EFKDWNPSTA RVHCFEEACV MVAEFIPADR
   181  KLSEAGFKAS NNRLFQLVMK GLLYECCVEF CQSKATGEEI TESEVLLGID LLCGNGCDDL
   241  DLSLLSWLQN LPSSVFSCAF EQKMLNIHVD KLLKPTKAAY ADLLTPLISK LSPYPSSPMR
   301  RPQSADAYMT RSLNPALDGL TCGLTSHDKR ISDLGNKTSP MSHSFANFHY PGVQNLSRSL
   361  MLENTECHSI YEESPERDTP VDAQRPIGSE ILGQSSVSEK EPANGAQNPG PAKQEKNELR
   421  DSTEQFQEYY RQRLRYQQHL EQKEQQRQIY QQMLLEGGVN QEDGPDQQQN LTEQFLNRSI
   481  QKLGELNIGM DGLGNEVSAL NQQCNGSKGN GSNGSSVTSF TTPPQDSSQR LTHDASNIHT
   541  STPRNPGSTN HIPFLEESPC GSQISSEHSV IKPPLGDSPG SLSRSKGEED DKSKKQFVCI
   601  NILEDTQAVR AVAFHPAGGL YAVGSNSKTL RVCAYPDVID PSAHETPKQP VVRFKRNKHH
   661  KGSIYCVAWS PCGQLLATGS NDKYVKVLPF NAETCNATGP DLEFSMHDGT IRDLAFMEGP
   721  ESGGAILISA GAGDCNIYTT DCQRGQGLHA LSGHTGHILA LYTWSGWMIA SGSQDKTVRF
   781  WDLRVPSCVR VVGTTFHGTG SAVASVAVDP SGRLLATGQE DSSCMLYDIR GGRMVQSYHP
   841  HSSDVRSVRF SPGAHYLLTG SYDMKIKVTD LQGDLTKQLP IMVVGEHKDK VIQCRWHTQD
   901  LSFLSSSADR TVTLWTYNG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR47 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 42 nTPM
retina: 34 nTPM
basal ganglia: 24 nTPM
cerebellum: 23 nTPM
hypothalamus: 23 nTPM
hippocampal formation: 22 nTPM

Single-cell type

cone photoreceptor cells: 219 nCPM
rod photoreceptor cells: 129 nCPM
basal keratinocytes: 105 nCPM
suprabasal keratinocytes: 101 nCPM
neutrophils: 96 nCPM
thymocytes: 93 nCPM

Immune cell

neutrophil: 22 nTPM
basophil: 18 nTPM
eosinophil: 7.1 nTPM
plasmacytoid DC: 6.3 nTPM
non-classical monocyte: 5.9 nTPM
myeloid DC: 5.8 nTPM

Brain region

cerebral cortex: 90 nTPM
basal ganglia: 88 nTPM
hippocampal formation: 79 nTPM
white matter: 73 nTPM
hypothalamus: 72 nTPM
pons: 66 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDR47.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 90 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

See cases
Neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.29
gnomAD missense Z: 2.75
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

adult locomotory behavior
anterior commissure morphogenesis
autophagy
cerebral cortex radial glia-guided migration
corpus callosum development
microtubule cytoskeleton organization
motor behavior
negative regulation of microtubule depolymerization
neural precursor cell proliferation
neuronal stem cell population maintenance
detection of hot stimulus involved in thermoception

Molecular functions

protein-containing complex binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
LIS1 homology motif
CTLH, C-terminal LisH motif
WD40/YVTN repeat-like-containing domain superfamily
WD40 repeat, conserved site
WD40-repeat-containing domain superfamily
TPL/SMU1, LisH-like dimerisation domain
WD domain, G-beta repeat
LisH-like dimerisation domain
WDR47
WDR47, cross-over region
WDR47 cross-over region

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR47 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MAP1S

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR47 as an antibody target. Whether an autoantibody or antibody against WDR47 could matter depends on whether native WDR47 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR47 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR47 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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