Seroatlas · Human Serome Atlas

WDR36

WD repeat-containing protein 36

Also known as: WDR36_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NI36
Gene: WDR36
Canonical length: 895 aa
Protein class: Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for WDR36 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

895 residues, UniProt reviewed canonical sequence.

>Q8NI36|WDR36
     1  MERASERRTA SALFAGFRAL GLFSNDIPHV VRFSALKRRF YVTTCVGKSF HTYDVQKLSL
    61  VAVSNSVPQD ICCMAADGRL VFAAYGNVFS AFARNKEIVH TFKGHKAEIH FLQPFGDHII
   121  SVDTDGILII WHIYSEEEYL QLTFDKSVFK ISAILHPSTY LNKILLGSEQ GSLQLWNVKS
   181  NKLLYTFPGW KVGVTALQQA PAVDVVAIGL MSGQVIIHNI KFNETLMKFR QDWGPITSIS
   241  FRTDGHPVMA AGSPCGHIGL WDLEDKKLIN QMRNAHSTAI AGLTFLHREP LLVTNGADNA
   301  LRIWIFDGPT GEGRLLRFRM GHSAPLTNIR YYGQNGQQIL SASQDGTLQS FSTVHEKFNK
   361  SLGHGLINKK RVKRKGLQNT MSVRLPPITK FAAEEARESD WDGIIACHQG KLSCSTWNYQ
   421  KSTIGAYFLK PKELKKDDIT ATAVDITSCG NFAVIGLSSG TVDVYNMQSG IHRGSFGKDQ
   481  AHKGSVRGVA VDGLNQLTVT TGSEGLLKFW NFKNKILIHS VSLSSSPNIM LLHRDSGILG
   541  LALDDFSISV LDIETRKIVR EFSGHQGQIN DMAFSPDGRW LISAAMDCSI RTWDLPSGCL
   601  IDCFLLDSAP LNVSMSPTGD FLATSHVDHL GIYLWSNISL YSVVSLRPLP ADYVPSIVML
   661  PGTCQTQDVE VSEETVEPSD ELIEYDSPEQ LNEQLVTLSL LPESRWKNLL NLDVIKKKNK
   721  PKEPPKVPKS APFFIPTIPG LVPRYAAPEQ NNDPQQSKVV NLGVLAQKSD FCLKLEEGLV
   781  NNKYDTALNL LKESGPSGIE TELRSLSPDC GGSIEVMQSF LKMIGMMLDR KRDFELAQAY
   841  LALFLKLHLK MLPSEPVLLE EITNLSSQVE ENWTHLQSLF NQSMCILNYL KSALL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

liver: 13 nTPM
tonsil: 11 nTPM
lymph node: 11 nTPM
skin: 9.5 nTPM
breast: 9.4 nTPM
bone marrow: 9.1 nTPM

Single-cell type

basal keratinocytes: 97 nCPM
suprabasal keratinocytes: 70 nCPM
erythrocyte progenitors: 66 nCPM
monocyte progenitors: 55 nCPM
hepatocytes: 53 nCPM
corticotrophs: 52 nCPM

Immune cell

non-classical monocyte: 5 nTPM
naive CD4 T-cell: 4.2 nTPM
myeloid DC: 4 nTPM
MAIT T-cell: 3.7 nTPM
T-reg: 3.7 nTPM
memory CD8 T-cell: 3.6 nTPM

Brain region

cerebellum: 11 nTPM
hypothalamus: 9.6 nTPM
choroid plexus: 9.4 nTPM
white matter: 9.4 nTPM
midbrain: 9.3 nTPM
cerebral cortex: 9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDR36.

Disease | AllUniProt

Conditions WDR36 is implicated in, by any mechanism.

Glaucoma 1, open angle, G (GLC1G) MIM:609887

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0
gnomAD missense Z: -1.8
DepMap mean gene effect: -1.56
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40 repeat, conserved site
WD40-repeat-containing domain superfamily
WDR36/Utp21, C-terminal domain
WDR36/Utp21, N-terminal domain
Utp21 specific WD40 associated putative domain
WDR36/Utp21 second beta-propeller domain
WDR36/Utp21 first beta-propeller

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR36 as an antibody target. Whether an autoantibody or antibody against WDR36 could matter depends on whether native WDR36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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