Seroatlas · Human Serome Atlas

WDR27

WD repeat-containing protein 27

Also known as: MGC43690, WDR27_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A2RRH5
Gene: WDR27
Ensembl: ENSG00000184465
Chromosome: 6
Canonical length: 827 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein with multiple WD repeats. Proteins with these repeats may form scaffolds for protein-protein interaction and play key roles in cell signalling. Alternative splicing results in multiple transcript variants, but the full-length structure of some of these variants cannot be determined. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

827 residues, UniProt reviewed canonical sequence.

>A2RRH5|WDR27
     1  MENPQDIFSS NGGCLSDIVI EKYLVESKES VSHVQLACSM QDCAFPLDGT ELCIWNTKDP
    61  SHQLLILRGH HQPITAMAFG NKVNPLLICS ASLDYVIMWN LDECREKVLQ GLVPRGTVMG
   121  SLLGKVLCLQ LSLDDHVVAV CAGNKIFMLD IETQAVRAEL QGHLGPVTAV EFCPWRAGTL
   181  ISASEDRGFK VWDHCTGSLI YSSSVLSAYP LLSLFIDAES RQLVTGCADG QLWIFSLMDG
   241  HHYRRVARVD LRKKTETFST RRVKSGLCSQ PEESQLPSTS ALGKGEQVEV TFPVLRLAPC
   301  DLSLIPNSAC GCLSSENTRC VWIGSSVGLF VFNLANLEVE AALYYKDFQS LSILLAGSCA
   361  LRNRTADQKV LCLLASLFGG KIAVLEINPA ALVRAQQCPS MGQSLSVPAS SCVLPTSPLY
   421  LGIAKEKSTK AASEQRRAAR NVMKDQRLVF HSKVRSSGYA SAPHVTMFSP KTNIKSEGKG
   481  SSRSRSSCAR EAYPVECAVP TKPGPQVAAA PTCTRVCCIQ YSGDGQWLAC GLANHLLLVF
   541  DASLTGTPAV FSGHDGAVNA VCWSQDRRWL LSAARDGTLR MWSARGAELA LLLGKDMFSK
   601  PIQSAQFYYI DAFILLSSGP EFQLLRYHID TCKDEIKRYK QKSKSKLICR LSTTGAVDMT
   661  SLSAVNDFYS HIVLAAGRNR TVEVFDLNAG CSAAVIAEAH SRPVHQICQN KGSSFTTQQP
   721  QAYNLFLTTA IGDGMRLWDL RTLRCERHFE GHPTRGYPCG IAFSPCGRFA ACGAEDRHAY
   781  VYEMGSSTFS HRLAGHTDTV TGVAFNPSAP QLATATLDGK LQLFLAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 7.4 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 7.4 nTPM
testis: 7.3 nTPM
ovary: 7 nTPM
cervix: 6.8 nTPM
fallopian tube: 6.6 nTPM
endometrium: 6 nTPM

Single-cell type

distal convoluted tubule cells: 138 nCPM
renal connecting tubule cells: 113 nCPM
proximal tubule cells: 107 nCPM
loop of henle epithelial cells: 104 nCPM
renal collecting duct principal cells: 91 nCPM
podocytes: 91 nCPM

Immune cell

naive CD4 T-cell: 1.6 nTPM
naive B-cell: 0.9 nTPM
MAIT T-cell: 0.8 nTPM
memory CD4 T-cell: 0.5 nTPM
memory CD8 T-cell: 0.5 nTPM
eosinophil: 0.4 nTPM

Brain region

choroid plexus: 17 nTPM
cerebellum: 10 nTPM
basal ganglia: 9.7 nTPM
cerebral cortex: 9.6 nTPM
hypothalamus: 9.5 nTPM
medulla oblongata: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: -0.59
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
Quinoprotein alcohol dehydrogenase-like superfamily
WD40/YVTN repeat-like-containing domain superfamily
WD domain, G-beta repeat
WD repeat-containing protein 27

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR27 as an antibody target. Whether an autoantibody or antibody against WDR27 could matter depends on whether native WDR27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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