Seroatlas · Human Serome Atlas

WDR25

WD repeat-containing protein 25

Also known as: C14orf67, MGC4645, WDR25_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q64LD2
Gene
WDR25
Ensembl
ENSG00000176473
Chromosome
14
Canonical length
544 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a protein containing 7 WD repeats. WD repeats are approximately 30 to 40-amino acid domains containing several conserved residues, typically having a Tryptophan-Aspartic acid dipeptide (WD) at the C-terminal end. WD domains are involved in protein-protein interactions in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

544 residues, UniProt reviewed canonical sequence.

>Q64LD2|WDR25
     1  MTARTLSLMA SLVAYDDSDS EAETEHAGSF NATGQQKDTS GVARPPGQDF ASGTLDVPKA
    61  GAQPTKHGSC EDPGGYRLPL AQLGRSDWGS CPSQRLQWPG KEPQVTFPIK EPSCSSLWTS
   121  HVPASHMPLA AARFKQVKLS RNFPKSSFHA QSESETVGKN GSSFQKKKCE DCVVPYTPRR
   181  LRQRQALSTE TGKGKDVEPQ GPPAGRAPAP LYVGPGVSEF IQPYLNSHYK ETTVPRKVLF
   241  HLRGHRGPVN TIQWCPVLSK SHMLLSTSMD KTFKVWNAVD SGHCLQTYSL HTEAVRAARW
   301  APCGRRILSG GFDFALHLTD LETGTQLFSG RSDFRITTLK FHPKDHNIFL CGGFSSEMKA
   361  WDIRTGKVMR SYKATIQQTL DILFLREGSE FLSSTDASTR DSADRTIIAW DFRTSAKISN
   421  QIFHERFTCP SLALHPREPV FLAQTNGNYL ALFSTVWPYR MSRRRRYEGH KVEGYSVGCE
   481  CSPGGDLLVT GSADGRVLMY SFRTASRACT LQGHTQACVG TTYHPVLPSV LATCSWGGDM
   541  KIWH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 13 nTPM
  • pituitary gland: 11 nTPM
  • basal ganglia: 11 nTPM
  • skeletal muscle: 10 nTPM
  • choroid plexus: 10 nTPM
  • adrenal gland: 9.8 nTPM

Single-cell type

  • pancreatic acinar cells: 209 nCPM
  • somatotrophs: 79 nCPM
  • pituitary stem cells: 65 nCPM
  • thyrotrophs: 65 nCPM
  • rod photoreceptor cells: 63 nCPM
  • lactotrophs: 62 nCPM

Immune cell

  • basophil: 34 nTPM
  • eosinophil: 25 nTPM
  • classical monocyte: 17 nTPM
  • non-classical monocyte: 16 nTPM
  • intermediate monocyte: 15 nTPM
  • myeloid DC: 15 nTPM

Brain region

  • pons: 13 nTPM
  • choroid plexus: 12 nTPM
  • cerebellum: 11 nTPM
  • cerebral cortex: 11 nTPM
  • midbrain: 11 nTPM
  • basal ganglia: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0
gnomAD missense Z
0.64
DepMap mean gene effect
-0.68
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR25 as an antibody target. Whether an autoantibody or antibody against WDR25 could matter depends on whether native WDR25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR25. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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