Seroatlas · Human Serome Atlas

WDR13

WD repeat-containing protein 13

Also known as: WDR13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H1Z4
Gene: WDR13
Ensembl: ENSG00000101940
Chromosome: X
Canonical length: 485 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Centriolar satellite

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. A similar protein in mouse is thought to be a negative regulator of the pancreatic beta cell proliferation. Mice lacking this gene exhibit increased pancreatic islet mass and higher serum insulin levels, and are mildly obese. [provided by RefSeq, Nov 2016]

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>Q9H1Z4|WDR13
     1  MAAVWQQVLA VDARYNAYRT PTFPQFRTQY IRRRSQLLRE NAKAGHPPAL RRQYLRLRGQ
    61  LLGQRYGPLS EPGSARAYSN SIVRSSRTTL DRMEDFEDDP RALGARGHRR SVSRGSYQLQ
   121  AQMNRAVYED RPPGSVVPTS AAEASRAMAG DTSLSENYAF AGMYHVFDQH VDEAVPRVRF
   181  ANDDRHRLAC CSLDGSISLC QLVPAPPTVL RVLRGHTRGV SDFAWSLSND ILVSTSLDAT
   241  MRIWASEDGR CIREIPDPDS AELLCCTFQP VNNNLTVVGN AKHNVHVMNI STGKKVKGGS
   301  SKLTGRVLAL SFDAPGRLLW AGDDRGSVFS FLFDMATGKL TKAKRLVVHE GSPVTSISAR
   361  SWVSREARDP SLLINACLNK LLLYRVVDNE GTLQLKRSFP IEQSSHPVRS IFCPLMSFRQ
   421  GACVVTGSED MCVHFFDVER AAKAAVNKLQ GHSAPVLDVS FNCDESLLAS SDASGMVIVW
   481  RREQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 182 nTPM

Expression across tissuesHPA

Tissue

pancreas: 182 nTPM
heart muscle: 143 nTPM
amygdala: 115 nTPM
hippocampal formation: 105 nTPM
liver: 103 nTPM
choroid plexus: 101 nTPM

Single-cell type

esophageal apical cells: 175 nCPM
fallopian tube ciliated cells: 148 nCPM
respiratory ciliated cells: 143 nCPM
pancreatic acinar cells: 128 nCPM
platelets: 121 nCPM
decidual stromal cells: 109 nCPM

Immune cell

basophil: 76 nTPM
non-classical monocyte: 58 nTPM
intermediate monocyte: 48 nTPM
classical monocyte: 43 nTPM
myeloid DC: 39 nTPM
NK-cell: 33 nTPM

Brain region

hippocampal formation: 85 nTPM
choroid plexus: 84 nTPM
cerebral cortex: 82 nTPM
amygdala: 82 nTPM
basal ganglia: 71 nTPM
white matter: 68 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.94
gnomAD missense Z: 3.29
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of type B pancreatic cell proliferation

Molecular functions

promoter-specific chromatin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR13 as an antibody target. Whether an autoantibody or antibody against WDR13 could matter depends on whether native WDR13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...