Seroatlas · Human Serome Atlas

WDPCP

WD repeat-containing and planar cell polarity effector protein fritz homolog

Also known as: BBS15, C2orf86, CPLANE5, fritz, FRITZ_HUMAN, hFrtz

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95876
Gene
WDPCP
Ensembl
ENSG00000143951
Chromosome
2
Canonical length
746 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nuclear bodies,Endoplasmic reticulum,Flagellar centriole

OverviewNCBI Gene

This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Canonical amino-acid sequenceUniProt

746 residues, UniProt reviewed canonical sequence.

>O95876|WDPCP
     1  MRREFCWDAY SKAAGSRASS PLPRQDRDSF CHQMSFCLTE LHLWSLKNTL HIADRDIGIY
    61  QYYDKKDPPA TEHGNLEKKQ KLAESRDYPW TLKNRRPEKL RDSLKELEEL MQNSRCVLSK
   121  WKNKYVCQLL FGSGVLVSLS LSGPQLEKVV IDRSLVGKLI SDTISDALLT DSFIILSFLA
   181  QNKLCFIQFT KKMESSDVNK RLEKLSALDY KIFYYEIPGP INKTTERHLA INCVHDRVVC
   241  WWPLVNDDAW PWAPISSEKD RANLLLLGYA QGRLEVLSSV RTEWDPLDVR FGTKQPYQVF
   301  TVEHSVSVDK EPMADSCIYE CIRNKIQCVS VTRIPLKSKA ISCCRNVTED KLILGCEDSS
   361  LILYETHRRV TLLAQTELLP SLISCHPSGA ILLVGSNQGE LQIFDMALSP INIQLLAEDR
   421  LPRETLQFSK LFDASSSLVQ MQWIAPQVVS QKGEGSDIYD LLFLRFERGP LGVLLFKLGV
   481  FTRGQLGLID IIFQYIHCDE IYEAINILSS MNWDTLGHQC FISMSAIVNH LLRQKLTPER
   541  EAQLETSLGT FYAPTRPLLD STILEYRDQI SKYARRFFHH LLRYQRFEKA FLLAVDVGAR
   601  DLFMDIHYLA LDKGELALAE VARKRASDID AESITSGVEL LGPLDRGDML NEAFIGLSLA
   661  PQGEDSFPDN LPPSCPTHRH ILQQRILNGS SNRQIIDRRN ELEKDICSGF LMTNTCNAED
   721  GELREDGREQ EIRDGGSLKM IHFGLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDPCP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • retina: 11 nTPM
  • bone marrow: 6.9 nTPM
  • skeletal muscle: 4.7 nTPM
  • heart muscle: 4.5 nTPM
  • testis: 4.4 nTPM
  • adipose tissue: 4.3 nTPM

Single-cell type

  • adipocytes: 2,893 nCPM
  • cardiomyocytes: 2,295 nCPM
  • myonuclei: 949 nCPM
  • respiratory ciliated cells: 622 nCPM
  • mesothelial cells: 565 nCPM
  • choroid plexus epithelial cells: 514 nCPM

Immune cell

  • basophil: 6.7 nTPM
  • NK-cell: 3.9 nTPM
  • MAIT T-cell: 3.7 nTPM
  • naive CD8 T-cell: 3.6 nTPM
  • naive B-cell: 3.2 nTPM
  • classical monocyte: 2.8 nTPM

Brain region

  • white matter: 88 nTPM
  • cerebellum: 85 nTPM
  • cerebral cortex: 81 nTPM
  • basal ganglia: 74 nTPM
  • pons: 70 nTPM
  • hippocampal formation: 67 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDPCP.

Disease | AllUniProt

Conditions WDPCP is implicated in, by any mechanism.

  • Bardet-Biedl syndrome 15 (BBS15) MIM:615992
  • Congenital heart defects, hamartomas of tongue, and polysyndactyly (CHDTHP) MIM:217085

Disease | GeneticClinVar

50 pathogenic / likely-pathogenic of 781 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0
gnomAD missense Z
0.9
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDPCP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDPCP as an antibody target. Whether an autoantibody or antibody against WDPCP could matter depends on whether native WDPCP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDPCP is annotated at the cell surface, where native WDPCP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label WDPCP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDPCP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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