Seroatlas · Human Serome Atlas

WBP2NL

Postacrosomal sheath WW domain-binding protein

Also known as: FLJ26145, GRAMD7, MGC26816, PAWP, WBP2L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ICG8
Gene: WBP2NL
Ensembl: ENSG00000183066
Chromosome: 22
Canonical length: 309 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

WBP2NL is a sperm-specific WW domain-binding protein that promotes meiotic resumption and pronuclear development during oocyte fertilization (Wu et al., 2007 [PubMed 17289678]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q6ICG8|WBP2NL
     1  MAVNQSHTEN RRGALIPNGE SLLKRSPNVE LSFPQRSEGS NVFSGRKTGT LFLTSYRVIF
    61  ITSCSISDPM LSFMMPFDLM TNLTVEQPVF AANFIKGTIQ AAPYGGWEGQ ATFKLVFRNG
   121  DAIEFAQLMV KAASAAARGF PLRTLNDWFS SMGIYVITGE GNMCTPQMPC SVIVYGAPPA
   181  GYGAPPPGYG APPAGYGAQP VGNEGPPVGY RASPVRYGAP PLGYGAPPAG YGAPPLGYGA
   241  PPLGYGTPPL GYGAPPLGYG APPAGNEGPP AGYRASPAGS GARPQESTAA QAPENEASLP
   301  SASSSQVHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WBP2NL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

testis: 17 nTPM
epididymis: 1.1 nTPM
amygdala: 0.6 nTPM
basal ganglia: 0.6 nTPM
breast: 0.6 nTPM
ovary: 0.6 nTPM

Single-cell type

late spermatids: 1,365 nCPM
early spermatids: 399 nCPM
late primary spermatocytes: 140 nCPM
early primary spermatocytes: 111 nCPM
rod photoreceptor cells: 90 nCPM
astrocytes: 90 nCPM

Immune cell

myeloid DC: 0.2 nTPM
T-reg: 0.2 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

white matter: 3.5 nTPM
medulla oblongata: 2.8 nTPM
spinal cord: 2.4 nTPM
cerebral cortex: 2.2 nTPM
midbrain: 2.2 nTPM
pons: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

egg activation
meiotic cell cycle
positive regulation of DNA-templated transcription
male pronucleus assembly

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WBP2NL as an antibody target. Whether an autoantibody or antibody against WBP2NL could matter depends on whether native WBP2NL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WBP2NL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WBP2NL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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