Seroatlas · Human Serome Atlas

WBP1L

WW domain binding protein 1-like

Also known as: C10orf26, FLJ20154, OPAL1, WBP1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NX94
Gene: WBP1L
Ensembl: ENSG00000166272
Chromosome: 10
Canonical length: 342 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Microtubules

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in CXCL12-activated CXCR4 signaling pathway. Predicted to act upstream of or within hemopoiesis and positive regulation of protein ubiquitination. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>Q9NX94|WBP1L
     1  MPFLLGLRQD KEACVGTNNQ SYICDTGHCC GQSQCCNYYY ELWWFWLVWT IIIILSCCCV
    61  CHHRRAKHRL QAQQRQHEIN LIAYREAHNY SALPFYFRFL PNYLLPPYEE VVNRPPTPPP
   121  PYSAFQLQQQ QLLPPQCGPA GGSPPGIDPT RGSQGAQSSP LSEPSRSSTR PPSIADPDPS
   181  DLPVDRAATK APGMEPSGSV AGLGELDPGA FLDKDAECRE ELLKDDSSEH GAPDSKEKTP
   241  GRHRRFTGDS GIEVCVCNRG HHDDDLKEFN TLIDDALDGP LDFCDSCHVR PPGDEEEGLC
   301  QSSEEQAREP GHPHLPRPPA CLLLNTINEQ DSPNSQSSSS PS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WBP1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 51 nTPM
tongue: 46 nTPM
adrenal gland: 42 nTPM
liver: 40 nTPM
parathyroid gland: 39 nTPM
thyroid gland: 39 nTPM

Single-cell type

late spermatids: 796 nCPM
podocytes: 196 nCPM
neutrophils: 196 nCPM
early spermatids: 182 nCPM
renal collecting duct intercalated cells: 176 nCPM
proximal tubule cells: 152 nCPM

Immune cell

non-classical monocyte: 20 nTPM
eosinophil: 16 nTPM
neutrophil: 15 nTPM
intermediate monocyte: 15 nTPM
NK-cell: 13 nTPM
classical monocyte: 12 nTPM

Brain region

medulla oblongata: 57 nTPM
choroid plexus: 49 nTPM
spinal cord: 44 nTPM
thalamus: 41 nTPM
midbrain: 40 nTPM
pons: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.64
gnomAD missense Z: 1.02
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin protein ligase binding

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WBP1L as an antibody target. Whether an autoantibody or antibody against WBP1L could matter depends on whether native WBP1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WBP1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WBP1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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