Seroatlas · Human Serome Atlas

WAPL

Wings apart-like protein homolog

Also known as: FOE, KIAA0261, WAPAL, WAPL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5K2
Gene: WAPL
Ensembl: ENSG00000062650
Chromosome: 10
Canonical length: 1190 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables ATP-dependent protein-DNA unloader activity. Involved in several processes, including negative regulation of DNA replication; negative regulation of sister chromatid cohesion; and protein localization to chromatin. Located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1190 residues, UniProt reviewed canonical sequence.

>Q7Z5K2|WAPL
     1  MTSRFGKTYS RKGGNGSSKF DEVFSNKRTT LSTKWGETTF MAKLGQKRPN FKPDIQEIPK
    61  KPKVEEESTG DPFGFDSDDE SLPVSSKNLA QVKCSSYSES SEAAQLEEVT SVLEANSKIS
   121  HVVVEDTVVS DKCFPLEDTL LGKEKSTNRI VEDDASISSC NKLITSDKVE NFHEEHEKNS
   181  HHIHKNADDS TKKPNAETTV ASEIKETNDT WNSQFGKRPE SPSEISPIKG SVRTGLFEWD
   241  NDFEDIRSED CILSLDSDPL LEMKDDDFKN RLENLNEAIE EDIVQSVLRP TNCRTYCRAN
   301  KTKSSQGASN FDKLMDGTSQ ALAKANSESS KDGLNQAKKG GVSCGTSFRG TVGRTRDYTV
   361  LHPSCLSVCN VTIQDTMERS MDEFTASTPA DLGEAGRLRK KADIATSKTT TRFRPSNTKS
   421  KKDVKLEFFG FEDHETGGDE GGSGSSNYKI KYFGFDDLSE SEDDEDDDCQ VERKTSKKRT
   481  KTAPSPSLQP PPESNDNSQD SQSGTNNAEN LDFTEDLPGV PESVKKPINK QGDKSKENTR
   541  KIFSGPKRSP TKAVYNARHW NHPDSEELPG PPVVKPQSVT VRLSSKEPNQ KDDGVFKAPA
   601  PPSKVIKTVT IPTQPYQDIV TALKCRREDK ELYTVVQHVK HFNDVVEFGE NQEFTDDIEY
   661  LLSGLKSTQP LNTRCLSVIS LATKCAMPSF RMHLRAHGMV AMVFKTLDDS QHHQNLSLCT
   721  AALMYILSRD RLNMDLDRAS LDLMIRLLEL EQDASSAKLL NEKDMNKIKE KIRRLCETVH
   781  NKHLDLENIT TGHLAMETLL SLTSKRAGDW FKEELRLLGG LDHIVDKVKE CVDHLSRDED
   841  EEKLVASLWG AERCLRVLES VTVHNPENQS YLIAYKDSQL IVSSAKALQH CEELIQQYNR
   901  AEDSICLADS KPLPHQNVTN HVGKAVEDCM RAIIGVLLNL TNDNEWGSTK TGEQDGLIGT
   961  ALNCVLQVPK YLPQEQRFDI RVLGLGLLIN LVEYSARNRH CLVNMETSCS FDSSICSGEG
  1021  DDSLRIGGQV HAVQALVQLF LERERAAQLA ESKTDELIKD APTTQHDKSG EWQETSGEIQ
  1081  WVSTEKTDGT EEKHKKEEED EELDLNKALQ HAGKHMEDCI VASYTALLLG CLCQESPINV
  1141  TTVREYLPEG DFSIMTEMLK KFLSFMNLTC AVGTTGQKSI SRVIEYLEHC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WAPL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

retina: 33 nTPM
testis: 33 nTPM
thymus: 31 nTPM
skeletal muscle: 27 nTPM
tonsil: 26 nTPM
bone marrow: 26 nTPM

Single-cell type

neutrophils: 315 nCPM
neutrophil progenitors: 282 nCPM
erythrocyte progenitors: 192 nCPM
late primary spermatocytes: 176 nCPM
microglia: 164 nCPM
sertoli cells: 164 nCPM

Immune cell

basophil: 15 nTPM
eosinophil: 7.7 nTPM
non-classical monocyte: 7.5 nTPM
T-reg: 6.1 nTPM
neutrophil: 5.5 nTPM
naive CD4 T-cell: 5.1 nTPM

Brain region

cerebellum: 29 nTPM
white matter: 25 nTPM
basal ganglia: 24 nTPM
thalamus: 24 nTPM
spinal cord: 23 nTPM
hypothalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.11
gnomAD pLI: 1
DepMap mean gene effect: -0.57
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ATP-dependent protein-DNA unloader activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Armadillo-type fold
WAPL domain
Wings apart-like protein, C-terminal
Wings apart-like protein
Wings apart-like protein regulation of heterochromatin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WAPL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WAPL as an antibody target. Whether an autoantibody or antibody against WAPL could matter depends on whether native WAPL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WAPL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WAPL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...