Seroatlas · Human Serome Atlas

VXN

Vexin

Also known as: C8orf46, MGC33510, VEXIN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TAG6
Gene
VXN
Ensembl
ENSG00000169085
Chromosome
8
Canonical length
207 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

Predicted to be involved in neuron differentiation. Predicted to be located in nucleus and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

207 residues, UniProt reviewed canonical sequence.

>Q8TAG6|VXN
     1  MMHQIYSCSD ENIEVFTTVI PSKVSSPARR RAKSSQHLLT KNVVIESDLY THQPLELLPH
    61  RGDRRDPGDR RRFGRLQTAR PPTAHPAKAS ARPVGISEPK TSNLCGNRAY GKSLIPPVPR
   121  ISVKTSASAS LEATAMGTEK GAVLMRGSRH LKKMTEEYPA LPQGAEASLP LTGSASCGVP
   181  GILRKMWTRH KKKSEYVGAT NSAFEAD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VXN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.73
Highest tissue expression
113 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 113 nTPM
  • spinal cord: 87 nTPM
  • cerebral cortex: 81 nTPM
  • amygdala: 56 nTPM
  • midbrain: 56 nTPM
  • basal ganglia: 42 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 40 nCPM
  • oligodendrocytes: 37 nCPM
  • brain excitatory neurons: 25 nCPM
  • proximal tubule cells: 15 nCPM
  • astrocytes: 14 nCPM
  • loop of henle epithelial cells: 13 nCPM

Immune cell

  • memory CD8 T-cell: 0.1 nTPM
  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • hippocampal formation: 223 nTPM
  • white matter: 133 nTPM
  • cerebral cortex: 129 nTPM
  • basal ganglia: 111 nTPM
  • midbrain: 79 nTPM
  • pons: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0.13
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Vexin domain
  • Vexin
  • Vexin domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VXN as an antibody target. Whether an autoantibody or antibody against VXN could matter depends on whether native VXN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VXN is annotated at the cell surface, where native VXN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VXN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VXN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...