Seroatlas · Human Serome Atlas

VWA7

von Willebrand factor A domain-containing protein 7

Also known as: C6orf27, G7c, NG37, VWA7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y334
Gene: VWA7
Ensembl: ENSG00000204396
Chromosome: 6
Canonical length: 891 aa
Protein class: Predicted secreted proteins
Subcellular location: Plasma membrane,Cytosol
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

891 residues, UniProt reviewed canonical sequence.

>Q9Y334|VWA7
     1  MLPTEVPQSH PGPSALLLLQ LLLPPTSAFF PNIWSLLAAP GSITHQDLTE EAALNVTLQL
    61  FLEQPPPGRP PLRLEDFLGR TLLADDLFAA YFGPGSSRRF RAALGEVSRA NAAQDFLPTS
   121  RNDPDLHFDA ERLGQGRARL VGALRETVVA ARALDHTLAR QRLGAALHAL QDFYSHSNWV
   181  ELGEQQPHPH LLWPRQELQN LAQVADPTCS DCEELSCPRN WLGFTLLTSG YFGTHPPKPP
   241  GKCSHGGHFD RSSSQPPRGG INKDSTSPGF SPHHMLHLQA AKLALLASIQ AFSLLRSRLG
   301  DRDFSRLLDI TPASSLSFVL DTTGSMGEEI NAAKIQARHL VEQRRGSPME PVHYVLVPFH
   361  DPGFGPVFTT SDPDSFWQQL NEIHALGGGD EPEMCLSALQ LALLHTPPLS DIFVFTDASP
   421  KDAFLTNQVE SLTQERRCRV TFLVTEDTSR VQGRARREIL SPLRFEPYKA VALASGGEVI
   481  FTKDQHIRDV AAIVGESMAA LVTLPLDPPV VVPGQPLVFS VDGLLQKITV RIHGDISSFW
   541  IKNPAGVSQG QEEGGGPLGH TRRFGQFWMV TMDDPPQTGT WEIQVTAEDT PGVRVQAQTS
   601  LDFLFHFGIP MEDGPHPGLY PLTQPVAGLQ TQLLVEVTGL GSRANPGDPQ PHFSHVILRG
   661  VPEGAELGQV PLEPVGPPER GLLAASLSPT LLSTPRPFSL ELIGQDAAGR RLHRAAPQPS
   721  TVVPVLLELS GPSGFLAPGS KVPLSLRIAS FSGPQDLDLR TFVNPSFSLT SNLSRAHLEL
   781  NESAWGRLWL EVPDSAAPDS VVMVTVTAGG REANPVPPTH AFLRLLVSAP APQDRHTTPT
   841  GSSDPILTTA TPAFSPFTLV TQGRAGAGLA AGSPWWGTVG GVLLLLGLAS W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VWA7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 20 nTPM
skeletal muscle: 6.2 nTPM
cerebral cortex: 6 nTPM
fallopian tube: 5.9 nTPM
kidney: 5.4 nTPM
endometrium: 5.3 nTPM

Single-cell type

fallopian tube ciliated cells: 3.1 nCPM
renal connecting tubule cells: 2.6 nCPM
renal collecting duct principal cells: 2.4 nCPM
podocytes: 2.3 nCPM
proximal tubule cells: 2.2 nCPM
loop of henle epithelial cells: 2.1 nCPM

Immune cell

basophil: 0.5 nTPM
T-reg: 0.2 nTPM
gdT-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 26 nTPM
pons: 22 nTPM
medulla oblongata: 16 nTPM
cerebral cortex: 15 nTPM
midbrain: 11 nTPM
white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 1.01
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

von Willebrand factor A-like domain superfamily
Hemicentin/VWA7, galactose-binding domain-like
Hemicentin-1-like, von Willebrand factor A domain
Hemicentin galactose-binding domain-like
von Willebrand factor A domain
VWA7
VWA7, N-terminal domain
VWA7, beta-sandwich domain
VWA7, Ig-like domain
VWA7 beta-sandwich domain
VWA7 Ig-like domain
VWA7 N-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VWA7 as an antibody target. Whether an autoantibody or antibody against VWA7 could matter depends on whether native VWA7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VWA7 is annotated as secreted, so native VWA7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label VWA7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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