Seroatlas · Human Serome Atlas

VWA5B2

von Willebrand factor A domain-containing protein 5B2

Also known as: DKFZp761K032, LOC90113, VW5B2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N398
Gene
VWA5B2
Ensembl
ENSG00000145198
Chromosome
3
Canonical length
1242 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

No narrative summary is available for VWA5B2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1242 residues, UniProt reviewed canonical sequence.

>Q8N398|VWA5B2
     1  MPGLYCPSSW TPLPLTDSWV RACANGPCLS VRARLTYRNP QPQPVDGVFV YPLAEAEVVS
    61  GFEAEAAGRR VSFQLQSRRR SQAACCRALG PGLGTPTPRR CAQGHLVLDL AQARSTLVLP
   121  TGIIAAAGTM TVTLHSSREL PSRPDGVLHV ALPTVLTPLA PPGPPGPPRP PGLCDDSPTS
   181  CFGVGSLQEE GLAWEELAAP RDVFSGPARC PAPYTFSFEM LVTGPCLLAG LESPSHALRA
   241  DAPPHASSAA TICVTLAEGH HCDRALEILL HPSEPHQPHL MLEGGSLSSA EYEARVRARR
   301  DFQRLQRRDS DGDRQVWFLQ RRFHKDILLN PVLALSFCPD LSSKPGHLGT ATRELLFLLD
   361  SSSVAHKDAI VLAVKSLPPQ TLINLAVFGT LVQPLFPESR PCSDDAVQLI CESIETLQVP
   421  SGPPDVLAAL DWAVGQPQHR AYPRQLFLLT AASPMAATTH RTLELMRWHR GTARCFSFGL
   481  GPTCHQLLQG LSALSRGQAY FLRPGQRLQP MLVQALRKAL EPALSDISVD WFVPDTVEAL
   541  LTPREIPALY PGDQLLGYCS LFRVDGFRSR PPGGQEPGWQ SSGGSVFPSP EEAPSAASPG
   601  TEPTGTSEPL GTGTVSAELS SPWAARDSEQ STDALTDPVT DPGPNPSDTA IWRRIFQSSY
   661  IREQYVLTHC SASPEPGPGS TGSSESPGSQ GPGSPEGSAP LEPPSQQGCR SLAWGEPAGS
   721  RSCPLPAPTP APFKVGALST EVLGRQHRAA LAGRSLSSPP GRANQVPGRP RKPSLGAILD
   781  GPSPEPGQQL GQGLDDSGNL LSPAPMDWDM LMEPPFLFTA VPPSGELAPP AVPPQAPRCH
   841  VVIRGLCGEQ PMCWEVGVGL ETLWGPGDGS QPPSPPVREA AWDQALHRLT AASVVRDNEQ
   901  LALRGGAETT ADRGHARRCW LRALQTSKVS SAPSCFTCPV AVDATTREVL PGALQVCSSE
   961  PAEPPGTPPA SHSHLDAAPL PTVVYSKGLQ RGSPAGAWDS DQNGNSKRAL GDPATPTEGP
  1021  RRPPPRPPCR LSMGRRHKLC SPDPGQANNS EGSDHDYLPL VRLQEAPGSF RLDAPFCAAV
  1081  RISQERLCRA SPFAVHRASL SPTSASLPWA LLGPGVGQGD SATASCSPSP SSGSEGPGQV
  1141  DSGRGSDTEA SEGAEGLGGT DLRGRTWATA VALAWLEHRC AAAFDEWELT AAKADCWLRA
  1201  QHLPDGLDLA ALKAAARGLF LLLRHWDQNL QLHLLCYSPA NV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VWA5B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 40 nTPM
  • cerebral cortex: 17 nTPM
  • cerebellum: 16 nTPM
  • amygdala: 15 nTPM
  • hippocampal formation: 14 nTPM
  • basal ganglia: 7.3 nTPM

Single-cell type

  • adrenal medulla cells: 255 nCPM
  • neuroendocrine cells: 86 nCPM
  • pancreatic islet cells: 66 nCPM
  • brain excitatory neurons: 44 nCPM
  • retinal ganglion cells: 39 nCPM
  • brain inhibitory neurons: 29 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 59 nTPM
  • amygdala: 39 nTPM
  • hippocampal formation: 36 nTPM
  • pons: 34 nTPM
  • medulla oblongata: 33 nTPM
  • white matter: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0
gnomAD missense Z
2.52
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VWA5B2 as an antibody target. Whether an autoantibody or antibody against VWA5B2 could matter depends on whether native VWA5B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VWA5B2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VWA5B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VWA5B2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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