Seroatlas · Human Serome Atlas

VWA5B1

von Willebrand factor A domain-containing protein 5B1

Also known as: FLJ32784, VW5B1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TIE3
Gene: VWA5B1
Ensembl: ENSG00000158816
Chromosome: 1
Canonical length: 1220 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Plasma membrane,Mitochondria,Cytosol
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1220 residues, UniProt reviewed canonical sequence.

>Q5TIE3|VWA5B1
     1  MPGLLNWITG AALPLTASDV TSCVSGYALG LTASLTYGNL EAQPFQGLFV YPLDECTTVI
    61  GFEAVIADRV VTVQIKDKAK LESGHFDASH VRSPTVTGNI LQDGVSIAPH SCTPGKVTLD
   121  EDLERILFVA NLGTIAPMEN VTIFISTSSE LPTLPSGAVR VLLPAVCAPT VPQFCTKSTG
   181  TSNQQAQGKD RHCFGAWAPG SWNKLCLATL LNTEVSNPME YEFNFQLEIR GPCLLAGVES
   241  PTHEIRADAA PSARSAKSII ITLANKHTFD RPVEILIHPS EPHMPHVLIE KGDMTLGEFD
   301  QHLKGRTDFI KGMKKKSRAE RKTEIIRKRL HKDIPHHSVI MLNFCPDLQS VQPCLRKAHG
   361  EFIFLIDRSS SMSGISMHRV KDAMLVALKS LMPACLFNII GFGSTFKSLF PSSQTYSEDS
   421  LAMACDDIQR MKADMGGTNI LSPLKWVIRQ PVHRGHPRLL FVITDGAVNN TGKVLELVRN
   481  HAFSTRCYSF GIGPNVCHRL VKGLASVSEG SAELLMEGER LQPKMVKSLK KAMAPVLSDV
   541  TVEWIFPETT EVLVSPVSAS SLFPGERLVG YGIVCDASLH ISNPRSDKRR RYSMLHSQES
   601  GSSVFYHSQD DGPGLEGGDC AKNSGAPFIL GQAKNARLAS GDSTTKHDLN LSQRRRAYST
   661  NQITNHKPLP RATMASDPMP AAKRYPLRKA RLQDLTNQTS LDVQRWQIDL QPLLNSGQDL
   721  NQGPKLRGPG ARRPSLLPQG CQPFLPWGQE TQAWSPVRER TSDSRSPGDL EPSHHPSAFE
   781  TETSSDWDPP AESQERASPS RPATPAPVLG KALVKGLHDS QRLQWEVSFE LGTPGPERGG
   841  AQDADLWSET FHHLAARAII RDFEQLAERE GEIEQGSNRR YQVSALHTSK ACNIISKYTA
   901  FVPVDVSKSR YLPTVVEYPN SAALRMLGSR ALAQQWRGTS SGFGRPQTML GEDSAPGNGK
   961  FQALNMEASP TALFSEARSP GREKHGASEG PQRSLATNTL SSMKASENLF GSWLNLNKSR
  1021  LLTRAAKGFL SKPLIKAVES TSGNQSFDYI PLVSLQLASG AFLLNEAFCE ATHIPMEKLK
  1081  WTSPFTCHRV SLTTRPSESK TPSPQLCTSS PPRHPSCDSF SLEPLAKGKL GLEPRAVVEH
  1141  TGKLWATVVG LAWLEHSSAS YFTEWELVAA KANSWLEQQE VPEGRTQGTL KAAARQLFVL
  1201  LRHWDENLEF NMLCYNPNYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VWA5B1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 13 nTPM
pituitary gland: 11 nTPM
kidney: 5 nTPM
hypothalamus: 3.8 nTPM
testis: 2.9 nTPM
epididymis: 2.8 nTPM

Single-cell type

somatotrophs: 295 nCPM
epididymal clear cells: 282 nCPM
choroid plexus epithelial cells: 263 nCPM
ependymal cells: 223 nCPM
renal collecting duct intercalated cells: 189 nCPM
papillary tip epithelial cells: 64 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 47 nTPM
midbrain: 16 nTPM
pons: 13 nTPM
medulla oblongata: 9.8 nTPM
hypothalamus: 7.7 nTPM
thalamus: 4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: 0.97

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VWA5B1 as an antibody target. Whether an autoantibody or antibody against VWA5B1 could matter depends on whether native VWA5B1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VWA5B1 is annotated as secreted, so native VWA5B1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label VWA5B1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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