Seroatlas · Human Serome Atlas

VWA3A

von Willebrand factor A domain-containing protein 3A

Also known as: FLJ40941, FLJ46765, VWA3A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NCI4
Gene: VWA3A
Ensembl: ENSG00000175267
Chromosome: 16
Canonical length: 1184 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1184 residues, UniProt reviewed canonical sequence.

>A6NCI4|VWA3A
     1  MKKYRKISIG CFAMATQTSH VFHGQENMFL ENHCIRRNTG RDSKKPLKQK NMNGLGQNSD
    61  NGLLVTHVNQ TQDLLRLQGS ETQSSDWEDS EDWLSAHSLK CQKLTLADLI SQGTEVLEEG
   121  TNVVQKICFS TQIIRHFESK LSDTIEVYQE RIQWLTENSK KAFGLIKGAR VSILIDVSAI
   181  SSGPQKEEFQ KDLMSLIDEQ LSHKEKLFVL SFGTNAGSLW PDPMEVSAST LQELKLWVKT
   241  LQPDGGSNLL QALKKIFTLK GLDSLVAIMR SCPDQPSEIL SDYIQQSTMG RDLIIHFITY
   301  RCDDQMPPAV LKNLAEAVRG YYHCYSPKME HYTSRDMDEL LAEIQKAQSL LSHVQALQHS
   361  SPCEALTCTM EEISTEITNG PLISLLPKPP KHDAPLTIEF PNLDKTSAEW LKVNGLKAKK
   421  LSLYQVLAPN AFSPVEEFVP ILQKTVSSTI HEKAMIQFEW HDGTVKNIHV DPPFLYKYQQ
   481  QLSRAMRMYE RRIEWLSLAS RRIWGTVCEK RVVVLLDISA TNSMYIIHIQ HSLRLLLEEQ
   541  LSNKDCFNLI AFGSTIESWR PEMVPVSHNN LQSAWRWALN LRCRGSRNVL SALRKAVEVD
   601  FKDKDKHQSQ GIYLFTGGIP DQDMPTLSAY MAEACGGCDL QLNVCLFYVG EPKMDTTPPA
   661  RYASHTDTAA AYKEVTRAAG GRFHWFGDTG IYESDDINSI MSEMEKALNY SQKCAFLMAS
   721  LKNHSGKVLG SSALPKEKPK TLQLRSQPKK LCPPRPTVPL GARMSIKDDP DREKSPPLKS
   781  LKWRPLSSRV GISPAAAQPT KEGMMELRRK TKSREAETSL LLFYTEKGND VGSVYKKYPQ
   841  GRGLRRTSSS IDLPRKDTVC SSQEWVAKYG LKKLKLEISR CMGPNCTHQK SGQRSASAKH
   901  CSIFPSVEIH GVVRHIQWTP REMEVYIRHL EKVLRRYVQR LQWLLSGSRR LFGTVLESKV
   961  CILLDTSGSM GPYLQQVKTE LVLLIWEQLR KCCDSFNLLS FAESFQSWQD TLVETTDAAC
  1021  HEAMQWVTHL QAQGSTSILQ ALLKAFSFHD LEGLYLLTDG KPDTSCSLVL NEVQKLREKR
  1081  DVKVHTISLN CSDRAAVEFL RKLASFTGGR YHCPVGEDTL SKIHSLLTKG FINEKDPTLP
  1141  PFEGDDLRIL AQEITKARSF LWQAQSFRSQ LQKKNDAEPK VTLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VWA3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 54 nTPM
fallopian tube: 31 nTPM
pituitary gland: 16 nTPM
lung: 8.9 nTPM
cerebral cortex: 8.7 nTPM
testis: 7.8 nTPM

Single-cell type

ependymal cells: 865 nCPM
choroid plexus epithelial cells: 300 nCPM
astrocytes: 44 nCPM
late spermatids: 22 nCPM
brain excitatory neurons: 21 nCPM
fallopian tube ciliated cells: 18 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 108 nTPM
midbrain: 58 nTPM
medulla oblongata: 45 nTPM
spinal cord: 30 nTPM
basal ganglia: 24 nTPM
pons: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.71
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VWA3A as an antibody target. Whether an autoantibody or antibody against VWA3A could matter depends on whether native VWA3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VWA3A is annotated as secreted, so native VWA3A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label VWA3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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