Seroatlas · Human Serome Atlas

VSTM5

V-set and transmembrane domain-containing protein 5

Also known as: C11orf90, LOC387804, VSTM5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MXK1
Gene: VSTM5
Ensembl: ENSG00000214376
Chromosome: 11
Canonical length: 200 aa
Protein class: Predicted membrane proteins
Subcellular location: Endoplasmic reticulum
Quaternary structure: Homooligomer

OverviewNCBI Gene

Predicted to be involved in several processes, including filopodium assembly; positive regulation of excitatory synapse assembly; and protein homooligomerization. Predicted to be located in membrane. Predicted to be active in axon; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

200 residues, UniProt reviewed canonical sequence.

>A8MXK1|VSTM5
     1  MRPLPSGRRK TRGISLGLFA LCLAAARCLQ SQGVSLYIPQ ATINATVKED ILLSVEYSCH
    61  GVPTIEWTYS SNWGTQKIVE WKPGTQANIS QSHKDRVCTF DNGSIQLFSV GVRDSGYYVI
   121  TVTERLGSSQ FGTIVLHVSE ILYEDLHFVA VILAFLAAVA AVLISLMWVC NKCAYKFQRK
   181  RRHKLKESTT EEIELEDVEC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VSTM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 4.5 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 4.5 nTPM
placenta: 4.1 nTPM
cerebral cortex: 3.5 nTPM
midbrain: 1.8 nTPM
stomach: 1.8 nTPM
hippocampal formation: 1.6 nTPM

Single-cell type

cytotrophoblasts: 76 nCPM
other brain neurons: 23 nCPM
migrating cytotrophoblasts: 18 nCPM
brain inhibitory neurons: 13 nCPM
brain excitatory neurons: 13 nCPM
gonadotrophs: 12 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 8.6 nTPM
cerebral cortex: 8.1 nTPM
pons: 7.3 nTPM
medulla oblongata: 6.3 nTPM
white matter: 5.2 nTPM
basal ganglia: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: 0.98
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VSTM5 as an antibody target. Whether an autoantibody or antibody against VSTM5 could matter depends on whether native VSTM5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VSTM5 is annotated at the cell surface, where native VSTM5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VSTM5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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