Seroatlas · Human Serome Atlas

VSTM1

V-set and transmembrane domain-containing protein 1

Also known as: UNQ3033, VSTM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UX27
Gene: VSTM1
Ensembl: ENSG00000189068
Chromosome: 19
Canonical length: 236 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to enable cytokine activity. Predicted to be involved in immune response-regulating signaling pathway. Predicted to be located in extracellular space and membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>Q6UX27|VSTM1
     1  MTAEFLSLLC LGLCLGYEDE KKNEKPPKPS LHAWPSSVVE AESNVTLKCQ AHSQNVTFVL
    61  RKVNDSGYKQ EQSSAENEAE FPFTDLKPKD AGRYFCAYKT TASHEWSESS EHLQLVVTDK
   121  HDELEAPSMK TDTRTIFVAI FSCISILLLF LSVFIIYRCS QHSSSSEEST KRTSHSKLPE
   181  QEAAEADLSN MERVSLSTAD PQGVTYAELS TSALSEAASD TTQEPPGSHE YAALKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VSTM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 41 nTPM
pituitary gland: 5 nTPM
spleen: 4.1 nTPM
pancreas: 1.3 nTPM
lung: 1 nTPM
urinary bladder: 0.5 nTPM

Single-cell type

neutrophil progenitors: 40 nCPM
late spermatids: 29 nCPM
gonadotrophs: 17 nCPM
neutrophils: 12 nCPM
monocytes: 6.9 nCPM
oocytes: 4.6 nCPM

Immune cell

eosinophil: 130 nTPM
non-classical monocyte: 8.2 nTPM
classical monocyte: 7.4 nTPM
intermediate monocyte: 7 nTPM
total PBMC: 4.8 nTPM
basophil: 4.4 nTPM

Brain region

cerebral cortex: 0.1 nTPM
hypothalamus: 0.1 nTPM
pons: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: -0.15
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cytokine activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VSTM1 as an antibody target. Whether an autoantibody or antibody against VSTM1 could matter depends on whether native VSTM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VSTM1 is annotated as secreted, so native VSTM1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label VSTM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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