Seroatlas · Human Serome Atlas

VSIG8

V-set and immunoglobulin domain-containing protein 8

Also known as: VSIG8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DPA2
Gene: VSIG8
Ensembl: ENSG00000243284
Chromosome: 1
Canonical length: 414 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

414 residues, UniProt reviewed canonical sequence.

>P0DPA2|VSIG8
     1  MRVGGAFHLL LVCLSPALLS AVRINGDGQE VLYLAEGDNV RLGCPYVLDP EDYGPNGLDI
    61  EWMQVNSDPA HHRENVFLSY QDKRINHGSL PHLQQRVRFA ASDPSQYDAS INLMNLQVSD
   121  TATYECRVKK TTMATRKVIV TVQARPAVPM CWTEGHMTYG NDVVLKCYAS GGSQPLSYKW
   181  AKISGHHYPY RAGSYTSQHS YHSELSYQES FHSSINQGLN NGDLVLKDIS RADDGLYQCT
   241  VANNVGYSVC VVEVKVSDSR RIGVIIGIVL GSLLALGCLA VGIWGLVCCC CGGSGAGGAR
   301  GAFGYGNGGG VGGGACGDLA SEIREDAVAP GCKASGRGSR VTHLLGYPTQ NVSRSLRRKY
   361  APPPCGGPED VALAPCTAAA ACEAGPSPVY VKVKSAEPAD CAEGPVQCKN GLLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VSIG8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

skin: 24 nTPM
tonsil: 6.1 nTPM
salivary gland: 4.9 nTPM
kidney: 4.4 nTPM
esophagus: 3.6 nTPM
cerebellum: 3.5 nTPM

Single-cell type

ependymal cells: 5 nCPM
choroid plexus epithelial cells: 1.3 nCPM
suprabasal keratinocytes: 0.6 nCPM
brain excitatory neurons: 0.3 nCPM
astrocytes: 0.1 nCPM
basal keratinocytes: 0.1 nCPM

Immune cell

gdT-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 5.7 nTPM
choroid plexus: 5 nTPM
pons: 4.5 nTPM
midbrain: 3.3 nTPM
medulla oblongata: 3.2 nTPM
spinal cord: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 0.86
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VSIG8 as an antibody target. Whether an autoantibody or antibody against VSIG8 could matter depends on whether native VSIG8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VSIG8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VSIG8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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