Seroatlas · Human Serome Atlas

VSIG10L2

V-set and immunoglobulin domain-containing protein 10-like 2

Also known as: VSXL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DP72
Gene: VSIG10L2
Ensembl: ENSG00000283703
Chromosome: 11
Canonical length: 767 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be located in membrane. Predicted to be active in cell-cell junction and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

767 residues, UniProt reviewed canonical sequence.

>P0DP72|VSIG10L2
     1  MVGQRAQHSP VSLLLLIHLC LLHLRASGQP HPTPEAPVEE VVSVQGVRGG SVELACGSGP
    61  APLLVLWSFT PLGSLVPRPV AVTDGAMSKV EAIASALGVV SLRNSSLVLG ELHEGARGHF
   121  LCQVLHVAGG QLHAAYSHLT LAVLVPVSKP QVRLSNPSPV EGASVVATCA VREGTEPVTF
   181  AWQHRAPRGL GEALVGVTEP LFQLDPVNRT HLGWYMCSAS NSVNRLSSDG AFLDVIYGPD
   241  KPVITMEPLG LTEEGFWASE REEVTLSCLA ASNPPSHYVW LRDHTQVHTG PTYVIARAGR
   301  VHTGLYTCLA RNSYLDTRTQ TTVQLTIYYP PEGQPSCAVH PSPEAVTLLC AWPGGLPPAQ
   361  LQWEGPQGPG PTAPSNVTWS HAAAQLPSGS VFTCTGQHPA LAPPALCTVM LWEPLGRPTC
   421  WSTATMGDQF IMLSCEWPGG EPPATLGWLD EQQQPLGGSS SSMAVHLLQA QEDLAGREFT
   481  CRGTHLLRTP DPHCHLQLEA PQLDVAEPRV SVLEGGEAWL ECSLRGGTPP AQLLWLGPQQ
   541  QKVDPGTSGF MLHPEGAQLR LGIYDADPAH HRGTYQCVAR NAVGNSSQSV LLEVLRYPAP
   601  PNVTISRLTY GRHRREVQLQ WAILGPGNLT GFLVQRKASA LGPGAGAWET AASDIEPESR
   661  GRRLGGLDPG VLYAFRILAL NHHTAGHPSE VKIPADPPFS AYPAVLGAAG TGMVVATVAS
   721  LLVFQYAARH PETFPRLETP TTTPGLDPAQ ETTDSPVNVT ITVTATP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VSIG10L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

skin: 17 nTPM
cerebellum: 4.4 nTPM
cervix: 2.4 nTPM
breast: 1.8 nTPM
vagina: 1.5 nTPM
colon: 1.4 nTPM

Single-cell type

epicardial cells: 127 nCPM
mesothelial cells: 32 nCPM
breast hormone-responsive cells: 24 nCPM
suprabasal keratinocytes: 21 nCPM
basal keratinocytes: 16 nCPM
fibro-adipogenic progenitors: 16 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 8.2 nTPM
cerebral cortex: 3.4 nTPM
pons: 2 nTPM
hippocampal formation: 1.9 nTPM
basal ganglia: 1.8 nTPM
hypothalamus: 1.7 nTPM

OntologyGO

Biological processes

cell-cell adhesion

Molecular functions

cell adhesion molecule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VSIG10L2 as an antibody target. Whether an autoantibody or antibody against VSIG10L2 could matter depends on whether native VSIG10L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VSIG10L2 is annotated at the cell surface, where native VSIG10L2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VSIG10L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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