Seroatlas · Human Serome Atlas

VPREB3

Pre-B lymphocyte protein 3

Also known as: 8HS20, VPRE3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKI3
Gene: VPREB3
Ensembl: ENSG00000128218
Chromosome: 22
Canonical length: 123 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>Q9UKI3|VPREB3
     1  MACRCLSFLL MGTFLSVSQT VLAQLDALLV FPGQVAQLSC TLSPQHVTIR DYGVSWYQQR
    61  AGSAPRYLLY YRSEEDHHRP ADIPDRFSAA KDEAHNACVL TISPVQPEDD ADYYCSVGYG
   121  FSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VPREB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 111 nTPM

Expression across tissuesHPA

Tissue

tonsil: 111 nTPM
lymph node: 105 nTPM
small intestine: 74 nTPM
spleen: 64 nTPM
epididymis: 49 nTPM
appendix: 39 nTPM

Single-cell type

b-cells: 199 nCPM
epididymal principal cells: 87 nCPM
plasma cells: 31 nCPM
foveolar cells: 8.9 nCPM
adrenal cortex cells: 6.6 nCPM
gastric chief cells: 4.4 nCPM

Immune cell

naive B-cell: 808 nTPM
memory B-cell: 757 nTPM
total PBMC: 18 nTPM
neutrophil: 1.1 nTPM
T-reg: 1 nTPM
basophil: 0.9 nTPM

Brain region

thalamus: 4.1 nTPM
choroid plexus: 3.7 nTPM
cerebellum: 3.5 nTPM
medulla oblongata: 2.3 nTPM
midbrain: 2.3 nTPM
pons: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0.09
gnomAD missense Z: -0.28
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

immune response

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VPREB3 as an antibody target. Whether an autoantibody or antibody against VPREB3 could matter depends on whether native VPREB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VPREB3 is annotated as secreted, so native VPREB3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label VPREB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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