Seroatlas · Human Serome Atlas

VNN2

Pantetheine hydrolase VNN2

Also known as: FOAP-4, GPI-80, VNN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95498
Gene
VNN2
Ensembl
ENSG00000112303
Chromosome
6
Canonical length
520 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>O95498|VNN2
     1  MVTSSFPISV AVFALITLQV GTQDSFIAAV YEHAVILPNK TETPVSQEDA LNLMNENIDI
    61  LETAIKQAAE QGARIIVTPE DALYGWKFTR ETVFPYLEDI PDPQVNWIPC QDPHRFGHTP
   121  VQARLSCLAK DNSIYVLANL GDKKPCNSRD STCPPNGYFQ YNTNVVYNTE GKLVARYHKY
   181  HLYSEPQFNV PEKPELVTFN TAFGRFGIFT CFDIFFYDPG VTLVKDFHVD TILFPTAWMN
   241  VLPLLTAIEF HSAWAMGMGV NLLVANTHHV SLNMTGSGIY APNGPKVYHY DMKTELGKLL
   301  LSEVDSHPLS SLAYPTAVNW NAYATTIKPF PVQKNTFRGF ISRDGFNFTE LFENAGNLTV
   361  CQKELCCHLS YRMLQKEENE VYVLGAFTGL HGRRRREYWQ VCTLLKCKTT NLTTCGRPVE
   421  TASTRFEMFS LSGTFGTEYV FPEVLLTEIH LSPGKFEVLK DGRLVNKNGS SGPILTVSLF
   481  GRWYTKDSLY SSCGTSNSAI TYLLIFILLM IIALQNIVML

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VNN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
66 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 66 nTPM
  • tonsil: 39 nTPM
  • lymph node: 36 nTPM
  • bone marrow: 30 nTPM
  • lung: 23 nTPM
  • appendix: 23 nTPM

Single-cell type

  • neutrophils: 2,013 nCPM
  • neutrophil progenitors: 80 nCPM
  • monocytes: 60 nCPM
  • hofbauer cells: 30 nCPM
  • b-cells: 22 nCPM
  • pancreatic duct cells: 20 nCPM

Immune cell

  • neutrophil: 479 nTPM
  • classical monocyte: 65 nTPM
  • memory B-cell: 40 nTPM
  • total PBMC: 40 nTPM
  • naive CD8 T-cell: 40 nTPM
  • NK-cell: 36 nTPM

Brain region

  • cerebral cortex: 5.4 nTPM
  • pons: 3 nTPM
  • medulla oblongata: 2.5 nTPM
  • choroid plexus: 2.4 nTPM
  • thalamus: 1.5 nTPM
  • white matter: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.57
gnomAD pLI
0
gnomAD missense Z
-0.47
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VNN2 as an antibody target. Whether an autoantibody or antibody against VNN2 could matter depends on whether native VNN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VNN2 is annotated at the cell surface, where native VNN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VNN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VNN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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