Seroatlas · Human Serome Atlas

VN1R5

Vomeronasal type-1 receptor 5

Also known as: VN1R5_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5H4
Gene: VN1R5
Canonical length: 357 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for VN1R5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>Q7Z5H4|VN1R5
     1  MLKLVIIENM AEIMLFSLDL LLFSTDILCF NFPSKMIKLP GFITIQIFFY PQASFGISAN
    61  TILLLFHIFT FVFSHRSKSI DMIISHLSLI HILLLFTQAI LVSLDFFGSQ NTQDDLRYKV
   121  IVFLNKVMRG LSICTPCLLS VLQAIISPSI FSLAKLKHPS ASHILGFFLF SWVLNMFIGV
   181  IFCCTLRLPP VKRGQSSVCH TALFLFAHEL HPQETVFHTN DFEGCHLYRV HGPLKRLHGD
   241  YFIQTIRGYL SAFTQPACPR VSPVKRASQA ILLLVSFVFT YWVDFTFSFS GGVTWINDSL
   301  LVWLQVIVAN SYAAISPLML IYADNQIFKT LQMLWFKYLS PPKLMLKFNR QCGSTKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VN1R5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

retina: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
appendix: 0 nTPM
bone marrow: 0 nTPM
breast: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 1.9 nTPM
amygdala: 1.7 nTPM
basal ganglia: 1.7 nTPM
hippocampal formation: 1.7 nTPM
white matter: 1.7 nTPM
cerebellum: 1.6 nTPM

OntologyGO

Biological processes

response to pheromone

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VN1R5 as an antibody target. Whether an autoantibody or antibody against VN1R5 could matter depends on whether native VN1R5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VN1R5 is annotated at the cell surface, where native VN1R5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VN1R5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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