Seroatlas · Human Serome Atlas

VN1R4

Vomeronasal type-1 receptor 4

Also known as: V1RL4, VN1R4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5H5
Gene: VN1R4
Ensembl: ENSG00000228567
Chromosome: 19
Canonical length: 301 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable pheromone receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; response to pheromone; and sensory perception of chemical stimulus. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

301 residues, UniProt reviewed canonical sequence.

>Q7Z5H5|VN1R4
     1  MASRYVAVGM ILSQTVVGVL GSFSVLLHYL SFYCTGCRLR STDLIVKHLI VANFLALRCK
    61  GVPQTMAAFG VRYFLNALGC KLVFYLHRVG RGVSIGTTCL LSVFQVITVS SRKSRWAKLK
   121  EKAPKHVGFS VLLCWIVCML VNIIFPMYVT GKWNYTNITV NEDLGYCSGG GNNKIAQTLR
   181  AMLLSFPDVL CLGLMLWVSS SMVCILHRHK QRVQHIDRSN LSPRASPENR ATQSILILVS
   241  TFVSSYTLSC LFQVCMALLD NPNSLLVNTS ALMSVCFPTL SPFVLMSCDP SVYRFCFAWK
   301  R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VN1R4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

testis: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early primary spermatocytes: 0.2 nCPM
early spermatids: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.45
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VN1R4 as an antibody target. Whether an autoantibody or antibody against VN1R4 could matter depends on whether native VN1R4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VN1R4 is annotated at the cell surface, where native VN1R4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VN1R4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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