Seroatlas · Human Serome Atlas

VN1R2

Vomeronasal type-1 receptor 2

Also known as: V1RL2, VN1R2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NFZ6
Gene: VN1R2
Ensembl: ENSG00000196131
Chromosome: 19
Canonical length: 395 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable pheromone receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; response to pheromone; and sensory perception of chemical stimulus. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>Q8NFZ6|VN1R2
     1  MTHTLYPTPF ALYPINISAA WHLGPLPVSC FVSNKYQCSL AFGATTGLRV LVVVVPQTQL
    61  SFLSSLCLVS LFLHSLVSAH GEKPTKPVGL DPTLFQVVVG ILGNFSLLYY YMFLYFRGYK
   121  PRSTDLILRH LTVADSLVIL SKRIPETMAT FGLKHFDNYF GCKFLLYAHR VGRGVSIGST
   181  CLLSVFQVIT INPRNSRWAE MKVKAPTYIG LSNILCWAFH MLVNAIFPIY TTGKWSNNNI
   241  TKKGDLGYCS APLSDEVTKS VYAALTSFHD VLCLGLMLWA SSSIVLVLYR HKQQVQHICR
   301  NNLYPNSSPG NRAIQSILAL VSTFALCYAL SFITYVYLAL FDNSSWWLVN TAALIIACFP
   361  TISPFVLMCR DPSRSRLCSI CCRRNRRFFH DFRKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VN1R2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 0.4 nTPM

Expression across tissuesHPA

Tissue

retina: 0.4 nTPM
testis: 0.4 nTPM
appendix: 0.3 nTPM
bone marrow: 0.3 nTPM
cerebral cortex: 0.3 nTPM
lymph node: 0.3 nTPM

Single-cell type

early spermatids: 23 nCPM
late spermatids: 11 nCPM
late primary spermatocytes: 0.6 nCPM
adrenal cortex cells: 0.4 nCPM
müller glia: 0.4 nCPM
early primary spermatocytes: 0.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 3.9 nTPM
cerebral cortex: 3.6 nTPM
white matter: 3.5 nTPM
basal ganglia: 3 nTPM
hippocampal formation: 2.9 nTPM
hypothalamus: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.27
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VN1R2 as an antibody target. Whether an autoantibody or antibody against VN1R2 could matter depends on whether native VN1R2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VN1R2 is annotated at the cell surface, where native VN1R2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VN1R2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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