Seroatlas · Human Serome Atlas

VN1R1

Vomeronasal type-1 receptor 1

Also known as: V1RL1, VN1R1_HUMAN, VNR19I1, ZVNH1, ZVNR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZP7
Gene: VN1R1
Ensembl: ENSG00000178201
Chromosome: 19
Canonical length: 353 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

353 residues, UniProt reviewed canonical sequence.

>Q9GZP7|VN1R1
     1  MVGDTLKLLS PLMTRYFFLL FYSTDSSDLN ENQHPLDFDE MAFGKVKSGI SFLIQTGVGI
    61  LGNSFLLCFY NLILFTGHKL RPTDLILSQL ALANSMVLFF KGIPQTMAAF GLKYLLNDTG
   121  CKFVFYYHRV GTRVSLSTIC LLNGFQAIKL NPSICRWMEI KIRSPRFIDF CCLLCWAPHV
   181  LMNASVLLLV NGPLNSKNSS AKNNYGYCSY KASKRFSSLH AVLYFSPDFM SLGFMVWASG
   241  SMVFFLYRHK QQVQHNHSNR LSCRPSQEAR ATHTIMVLVS SFFVFYSVHS FLTIWTTVVA
   301  NPGQWIVTNS VLVASCFPAR SPFVLIMSDT HISQFCFACR TRKTLFPNLV VMP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VN1R1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 7.6 nTPM

Expression across tissuesHPA

Tissue

retina: 7.6 nTPM
cerebellum: 6.6 nTPM
pituitary gland: 3.2 nTPM
tongue: 2.5 nTPM
basal ganglia: 2.4 nTPM
cerebral cortex: 2.2 nTPM

Single-cell type

epididymal efferent duct absorptive cells: 0.1 nCPM
lactotrophs: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

naive B-cell: 0.3 nTPM
memory B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 12 nTPM
basal ganglia: 7.7 nTPM
cerebral cortex: 7.7 nTPM
hippocampal formation: 7.5 nTPM
amygdala: 7.3 nTPM
white matter: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.22
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VN1R1 as an antibody target. Whether an autoantibody or antibody against VN1R1 could matter depends on whether native VN1R1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VN1R1 is annotated at the cell surface, where native VN1R1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VN1R1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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