Seroatlas · Human Serome Atlas

VMO1

Vitelline membrane outer layer protein 1 homolog

Also known as: VMO1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5L0
Gene: VMO1
Ensembl: ENSG00000182853
Chromosome: 17
Canonical length: 202 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>Q7Z5L0|VMO1
     1  MERGAGAKLL PLLLLLRATG FTCAQTDGRN GYTAVIEVTS GGPWGDWAWP EMCPDGFFAS
    61  GFSLKVEPPQ GIPGDDTALN GIRLHCARGN VLGNTHVVES QSGSWGEWSE PLWCRGGAYL
   121  VAFSLRVEAP TTLGDNTAAN NVRFRCSDGE ELQGPGLSWG DFGDWSDHCP KGACGLQTKI
   181  QGPRGLGDDT ALNDARLFCC RS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VMO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 29 nTPM
spleen: 23 nTPM
choroid plexus: 14 nTPM
blood vessel: 13 nTPM
parathyroid gland: 13 nTPM
skeletal muscle: 11 nTPM

Single-cell type

conjunctival goblet cells: 6,465 nCPM
respiratory secretory cells: 774 nCPM
respiratory deuterosomal cells: 569 nCPM
salivary duct cells: 221 nCPM
kupffer cells: 121 nCPM
endometrial secretory cells: 111 nCPM

Immune cell

non-classical monocyte: 112 nTPM
myeloid DC: 12 nTPM
intermediate monocyte: 9.7 nTPM
total PBMC: 3.7 nTPM
NK-cell: 0.4 nTPM
classical monocyte: 0.2 nTPM

Brain region

choroid plexus: 7.2 nTPM
medulla oblongata: 6 nTPM
white matter: 6 nTPM
spinal cord: 4.4 nTPM
thalamus: 4.2 nTPM
cerebral cortex: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: -0.17
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Vitelline membrane outer layer protein I (VOMI)
Vitelline membrane outer layer protein I (VOMI) superfamily
Vitelline membrane outer layer protein I (VOMI)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VMO1 as an antibody target. Whether an autoantibody or antibody against VMO1 could matter depends on whether native VMO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VMO1 is annotated as secreted, so native VMO1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label VMO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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