Seroatlas · Human Serome Atlas

VMAC

Vimentin-type intermediate filament-associated coiled-coil protein

Also known as: VMAC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2NL98
Gene
VMAC
Ensembl
ENSG00000187650
Chromosome
19
Canonical length
169 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in cytoplasm. Predicted to be active in type III intermediate filament. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

169 residues, UniProt reviewed canonical sequence.

>Q2NL98|VMAC
     1  MSAPPALQIR EANAHLAAVH RRAAELEARL DAAERTVHAQ AERLALHDQQ LRAALDELGR
    61  AKDREIATLQ EQLMTSEATV HSLQATVHQR DELIRQLQPR AELLQDICRR RPPLAGLLDA
   121  LAEAERLGPL PASDPGHPPP GGPGPPLDNS TGEEADRDHL QPAVFGTTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VMAC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
7.5 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 7.5 nTPM
  • stomach: 7.3 nTPM
  • prostate: 6.9 nTPM
  • thyroid gland: 6.9 nTPM
  • salivary gland: 6.7 nTPM
  • pituitary gland: 6.6 nTPM

Single-cell type

  • late spermatids: 8 nCPM
  • gastric chief cells: 5.5 nCPM
  • early spermatids: 5 nCPM
  • late primary spermatocytes: 2 nCPM
  • endometrial ciliated cells: 1.6 nCPM
  • endometrial secretory cells: 1.3 nCPM

Immune cell

  • basophil: 6.6 nTPM
  • non-classical monocyte: 6.3 nTPM
  • T-reg: 6 nTPM
  • plasmacytoid DC: 5.9 nTPM
  • naive CD4 T-cell: 5.4 nTPM
  • naive CD8 T-cell: 5.2 nTPM

Brain region

  • white matter: 24 nTPM
  • medulla oblongata: 19 nTPM
  • pons: 17 nTPM
  • basal ganglia: 17 nTPM
  • cerebral cortex: 17 nTPM
  • thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.75
gnomAD pLI
0.04
gnomAD missense Z
0.26
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VMAC as an antibody target. Whether an autoantibody or antibody against VMAC could matter depends on whether native VMAC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VMAC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VMAC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VMAC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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