Seroatlas · Human Serome Atlas

VKORC1L1

Vitamin K epoxide reductase complex subunit 1-like protein 1

Also known as: VKORL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N0U8
Gene
VKORC1L1
Ensembl
ENSG00000196715
Chromosome
7
Canonical length
176 aa
Protein class
Enzymes, FDA approved drug targets, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes an enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane proteins form oxidative damage. This gene and a related gene (Gene ID: 79001) may have arisen by gene duplication of an ancestral gene. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

176 residues, UniProt reviewed canonical sequence.

>Q8N0U8|VKORC1L1
     1  MAAPVLLRVS VPRWERVARY AVCAAGILLS IYAYHVEREK ERDPEHRALC DLGPWVKCSA
    61  ALASRWGRGF GLLGSIFGKD GVLNQPNSVF GLIFYILQLL LGMTASAVAA LILMTSSIMS
   121  VVGSLYLAYI LYFVLKEFCI ICIVTYVLNF LLLIINYKRL VYLNEAWKRQ LQPKQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VKORC1L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 51 nTPM
  • parathyroid gland: 32 nTPM
  • breast: 23 nTPM
  • liver: 21 nTPM
  • skeletal muscle: 20 nTPM
  • lung: 17 nTPM

Single-cell type

  • adipocytes: 590 nCPM
  • platelets: 199 nCPM
  • transitional alveolar cells: 182 nCPM
  • alveolar cells type 1: 180 nCPM
  • alveolar cells type 2: 171 nCPM
  • megakaryocyte-erythroid progenitors: 148 nCPM

Immune cell

  • plasmacytoid DC: 3.5 nTPM
  • NK-cell: 2.9 nTPM
  • eosinophil: 2.7 nTPM
  • non-classical monocyte: 2.2 nTPM
  • basophil: 1.9 nTPM
  • memory CD4 T-cell: 1.5 nTPM

Brain region

  • medulla oblongata: 45 nTPM
  • cerebral cortex: 32 nTPM
  • midbrain: 29 nTPM
  • pons: 29 nTPM
  • hippocampal formation: 27 nTPM
  • white matter: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.84
gnomAD missense Z
1.79
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VKORC1L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VKORC1L1 as an antibody target. Whether an autoantibody or antibody against VKORC1L1 could matter depends on whether native VKORC1L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VKORC1L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VKORC1L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VKORC1L1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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