Seroatlas · Human Serome Atlas

VGLL1

Transcription cofactor vestigial-like protein 1

Also known as: TDU, TONDU, VGLL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99990
Gene: VGLL1
Ensembl: ENSG00000102243
Chromosome: X
Canonical length: 258 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

258 residues, UniProt reviewed canonical sequence.

>Q99990|VGLL1
     1  MEEMKKTAIR LPKGKQKPIK TEWNSRCVLF TYFQGDISSV VDEHFSRALS NIKSPQELTP
    61  SSQSEGVMLK NDDSMSPNQW RYSSPWTKPQ PEVPVTNRAA NCNLHVPGPM AVNQFSPSLA
   121  RRASVRPGEL WHFSSLAGTS SLEPGYSHPF PARHLVPEPQ PDGKREPLLS LLQQDRCLAR
   181  PQESAARENG NPGQIAGSTG LLFNLPPGSV HYKKLYVSRG SASTSLPNET LSELETPGKY
   241  SLTPPNHWGH PHRYLQHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VGLL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 192 nTPM

Expression across tissuesHPA

Tissue

placenta: 192 nTPM
urinary bladder: 21 nTPM
kidney: 6.9 nTPM
seminal vesicle: 6.3 nTPM
salivary gland: 5.2 nTPM
breast: 2.4 nTPM

Single-cell type

syncytiotrophoblasts: 2,022 nCPM
cytotrophoblasts: 1,559 nCPM
migrating cytotrophoblasts: 1,157 nCPM
extravillous trophoblasts: 628 nCPM
urothelial cells: 47 nCPM
prostatic club cells: 36 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.2 nTPM
amygdala: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM
thalamus: 0.1 nTPM
white matter: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0.81
gnomAD missense Z: 0.49
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transcription coactivator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VGLL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VGLL1 as an antibody target. Whether an autoantibody or antibody against VGLL1 could matter depends on whether native VGLL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VGLL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VGLL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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