Seroatlas · Human Serome Atlas

VGF

Neurosecretory protein VGF

Also known as: SCG7, SgVII, VGF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15240
Gene
VGF
Ensembl
ENSG00000128564
Chromosome
7
Canonical length
615 aa
Protein class
Plasma proteins, Predicted secreted proteins
Subcellular location
Golgi apparatus,Vesicles
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

615 residues, UniProt reviewed canonical sequence.

>O15240|VGF
     1  MKALRLSASA LFCLLLINGL GAAPPGRPEA QPPPLSSEHK EPVAGDAVPG PKDGSAPEVR
    61  GARNSEPQDE GELFQGVDPR ALAAVLLQAL DRPASPPAPS GSQQGPEEEA AEALLTETVR
   121  SQTHSLPAPE SPEPAAPPRP QTPENGPEAS DPSEELEALA SLLQELRDFS PSSAKRQQET
   181  AAAETETRTH TLTRVNLESP GPERVWRASW GEFQARVPER APLPPPAPSQ FQARMPDSGP
   241  LPETHKFGEG VSSPKTHLGE ALAPLSKAYQ GVAAPFPKAR RPESALLGGS EAGERLLQQG
   301  LAQVEAGRRQ AEATRQAAAQ EERLADLASD LLLQYLLQGG ARQRGLGGRG LQEAAEERES
   361  AREEEEAEQE RRGGEERVGE EDEEAAEAEA EAEEAERARQ NALLFAEEED GEAGAEDKRS
   421  QEETPGHRRK EAEGTEEGGE EEDDEEMDPQ TIDSLIELST KLHLPADDVV SIIEEVEEKR
   481  KRKKNAPPEP VPPPRAAPAP THVRSPQPPP PAPAPARDEL PDWNEVLPPW DREEDEVYPP
   541  GPYHPFPNYI RPRTLQPPSA LRRRHYHHAL PPSRHYPGRE AQARRAQEEA EAEERRLQEQ
   601  EELENYIEHV LLRRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VGF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
144 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 144 nTPM
  • pituitary gland: 91 nTPM
  • cerebral cortex: 55 nTPM
  • basal ganglia: 46 nTPM
  • amygdala: 23 nTPM
  • hippocampal formation: 17 nTPM

Single-cell type

  • pancreatic islet cells: 911 nCPM
  • other brain neurons: 102 nCPM
  • retinal horizontal cells: 96 nCPM
  • neuroendocrine cells: 69 nCPM
  • gonadotrophs: 53 nCPM
  • brain inhibitory neurons: 45 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 2,693 nTPM
  • medulla oblongata: 471 nTPM
  • cerebral cortex: 360 nTPM
  • pons: 345 nTPM
  • thalamus: 128 nTPM
  • midbrain: 124 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about VGF.

Disease | ImmuneIEDB

Conditions an epitope on VGF was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.57
gnomAD missense Z
0.25
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Neurosecretory protein VGF

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VGF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VGF as an antibody target. Whether an autoantibody or antibody against VGF could matter depends on whether native VGF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VGF is annotated as secreted, so native VGF circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label VGF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VGF. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...