Seroatlas · Human Serome Atlas

VEZT

Vezatin

Also known as: DKFZP761C241, VEZA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBM0
Gene: VEZT
Ensembl: ENSG00000028203
Chromosome: 12
Canonical length: 779 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

779 residues, UniProt reviewed canonical sequence.

>Q9HBM0|VEZT
     1  MTPEFDEEVV FENSPLYQYL QDLGHTDFEI CSSLSPKTEK CTTEGQQKPP TRVLPKQGIL
    61  LKVAETIKSW IFFSQCNKKD DLLHKLDIGF RLDSLHTILQ QEVLLQEDVE LIELLDPSIL
   121  SAGQSQQQEN GHLPTLCSLA TPNIWDLSML FAFISLLVML PTWWIVSSWL VWGVILFVYL
   181  VIRALRLWRT AKLQVTLKKY SVHLEDMATN SRAFTNLVRK ALRLIQETEV ISRGFTLVSA
   241  ACPFNKAGQH PSQHLIGLRK AVYRTLRANF QAARLATLYM LKNYPLNSES DNVTNYICVV
   301  PFKELGLGLS EEQISEEEAH NFTDGFSLPA LKVLFQLWVA QSSEFFRRLA LLLSTANSPP
   361  GPLLTPALLP HRILSDVTQG LPHAHSACLE ELKRSYEFYR YFETQHQSVP QCLSKTQQKS
   421  RELNNVHTAV RSLQLHLKAL LNEVIILEDE LEKLVCTKET QELVSEAYPI LEQKLKLIQP
   481  HVQASNNCWE EAISQVDKLL RRNTDKKGKP EIACENPHCT VVPLKQPTLH IADKDPIPEE
   541  QELEAYVDDI DIDSDFRKDD FYYLSQEDKE RQKREHEESK RVLQELKSVL GFKASEAERQ
   601  KWKQLLFSDH AVLKSLSPVD PVEPISNSEP SMNSDMGKVS KNDTEEESNK SATTDNEISR
   661  TEYLCENSLE GKNKDNSSNE VFPQGAEERM CYQCESEDEP QADGSGLTTA PPTPRDSLQP
   721  SIKQRLARLQ LSPDFTFTAG LAAEVAARSL SFTTMQEQTF GGEEEEQIIE ENKNEIEEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VEZT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 21 nTPM
tongue: 19 nTPM
thyroid gland: 13 nTPM
retina: 11 nTPM
blood vessel: 8.4 nTPM
cerebral cortex: 8.3 nTPM

Single-cell type

urothelial cells: 276 nCPM
myonuclei: 270 nCPM
syncytiotrophoblasts: 269 nCPM
lactotrophs: 257 nCPM
thyrotrophs: 255 nCPM
rod photoreceptor cells: 255 nCPM

Immune cell

memory B-cell: 2.4 nTPM
memory CD4 T-cell: 2.2 nTPM
MAIT T-cell: 2.1 nTPM
myeloid DC: 2 nTPM
naive B-cell: 1.8 nTPM
T-reg: 1.8 nTPM

Brain region

cerebellum: 25 nTPM
hypothalamus: 18 nTPM
cerebral cortex: 18 nTPM
basal ganglia: 17 nTPM
white matter: 16 nTPM
thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.11
gnomAD missense Z: 0.7
DepMap mean gene effect: -0.45
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell-cell adhesion

Molecular functions

myosin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Vezatin
Myosin-binding domain
Mysoin-binding motif of peroxisomes

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VEZT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

USH2A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VEZT as an antibody target. Whether an autoantibody or antibody against VEZT could matter depends on whether native VEZT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VEZT is annotated at the cell surface, where native VEZT is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VEZT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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