Seroatlas · Human Serome Atlas

VEPH1

Ventricular zone-expressed PH domain-containing protein homolog 1

Also known as: FLJ12604, KIAA1692, MELT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14D04
Gene: VEPH1
Ensembl: ENSG00000197415
Chromosome: 3
Canonical length: 833 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable phosphatidylinositol-5-phosphate binding activity. Involved in negative regulation of SMAD protein signal transduction and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in endomembrane system. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

833 residues, UniProt reviewed canonical sequence.

>Q14D04|VEPH1
     1  MHQLFRLVLG QKDLSRAGDL FSLDDSEIED SLTEALEQIK IISSSSDYQT NNNDQAVVEI
    61  CITRITTAIR ETESIEKHAK ALVGLWDSCL EHNLRPFGKD EDTPHAKIAS DIMSCILQNY
   121  NRPPVMALAI PIAVKFLHRG NKELCRNMSN YLSLAAITKA DLLADHTEVI VKSILQGNTM
   181  LLRVLPAVYE KQPQPINRHL TELLALMSQL EQPEQYHLLR LLHVAAKKKQ LEVVQKCIPF
   241  LIGHLKDSTH NDIILNILIE IAVYEPVALN SFLPMLKEIG ERFPYLTGQM ARIYGAVGHV
   301  DEERARSCLT YLVSQLANME HSFHHILLLE IKSITDTFSS ILGPQSRDIF RMSNSFTAIA
   361  KLLTRQLENT KAGSGRRKIS TEIEFPEKLE ETKLIVTENE DHEKLQVKIQ AFEDKINAGS
   421  NTPGSIRRYS LGQVSKEERK NIRFNRSKSL AFHTMLTKGV GSDDGEDENR GDIPASISLS
   481  EIDPLGQGND KLPFKTDTER SQLGESSVSY PNIIHIDSEN LSETVKENSQ EETPETTASP
   541  IEYQDKLYLH LKKNLSKVKA YAMEIGKKIP VPDQCTIEDT VRSCVAKLFF TCSLKGHYCL
   601  YSKSSFILIS QEPQPWIQIM FLFQQSLFPE PLSIQSHSVQ FLRALWEKTQ AGGAHSFETA
   661  MMESTFPQQK DLDQVQLHLE EVRFFDVFGF SETAGAWQCF MCNNPEKATV VNQDGQPLIE
   721  GKLKEKQVRW KFIKRWKTRY FTLAGNQLLF QKGKSKDDPD DCPIELSKVQ SVKAVAKKRR
   781  DRSLPRAFEI FTDNKTYVFK AKDEKNAEEW LQCINVAVAQ AKERESREVT TYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VEPH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

lung: 28 nTPM
kidney: 25 nTPM
adrenal gland: 19 nTPM
epididymis: 17 nTPM
pituitary gland: 15 nTPM
pancreas: 12 nTPM

Single-cell type

pituitary stem cells: 947 nCPM
alveolar cells type 2: 384 nCPM
adrenal cortex cells: 292 nCPM
transitional alveolar cells: 236 nCPM
renal collecting duct principal cells: 229 nCPM
alveolar cells type 1: 215 nCPM

Immune cell

total PBMC: 1.7 nTPM
neutrophil: 0.5 nTPM
intermediate monocyte: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

choroid plexus: 24 nTPM
pons: 6.6 nTPM
medulla oblongata: 4.1 nTPM
midbrain: 2.3 nTPM
hippocampal formation: 2.1 nTPM
cerebellum: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: -0.21
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phosphatidylinositol-5-phosphate binding

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VEPH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TGFBR1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VEPH1 as an antibody target. Whether an autoantibody or antibody against VEPH1 could matter depends on whether native VEPH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VEPH1 is annotated at the cell surface, where native VEPH1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VEPH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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