VEGFD

Protein identityUniProt · HPA

UniProt accession

O43915

Gene

VEGFD

Ensembl

ENSG00000165197

Chromosome

X

Canonical length

354 aa

Protein class

Cancer-related genes, Plasma proteins, Predicted secreted proteins, RAS pathway related proteins

Secretome location

Secreted to blood

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>O43915|VEGFD
     1  MYREWVVVNV FMMLYVQLVQ GSSNEHGPVK RSSQSTLERS EQQIRAASSL EELLRITHSE
    61  DWKLWRCRLR LKSFTSMDSR SASHRSTRFA ATFYDIETLK VIDEEWQRTQ CSPRETCVEV
   121  ASELGKSTNT FFKPPCVNVF RCGGCCNEES LICMNTSTSY ISKQLFEISV PLTSVPELVP
   181  VKVANHTGCK CLPTAPRHPY SIIRRSIQIP EEDRCSHSKK LCPIDMLWDS NKCKCVLQEE
   241  NPLAGTEDHS HLQEPALCGP HMMFDEDRCE CVCKTPCPKD LIQHPKNCSC FECKESLETC
   301  CQKHKLFHPD TCSCEDRCPF HTRPCASGKT ACAKHCRFPK EKRAAQGPHS RKNP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VEGFD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.46

Highest tissue expression

40 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.15

gnomAD pLI

0

DepMap mean gene effect

0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• dopaminergic neuron differentiation
• fibroblast proliferation
• induction of positive chemotaxis
• positive regulation of cell division
• positive regulation of cell population proliferation
• positive regulation of mast cell chemotaxis
• response to bacterium
• response to hypoxia
• sprouting angiogenesis
• vascular endothelial growth factor receptor signaling pathway
• vascular endothelial growth factor signaling pathway

Molecular functions

• chemoattractant activity
• growth factor activity
• identical protein binding
• platelet-derived growth factor receptor binding
• vascular endothelial growth factor receptor 3 binding
• vascular endothelial growth factor receptor binding

Cellular components

• extracellular region
• extracellular space
• membrane
• platelet alpha granule lumen

Protein domainsUniProt · Pfam · InterPro

• PDGF/VEGF domain
• CXCXC repeat
• Platelet-derived growth factor, conserved site
• Cystine-knot cytokine
• Platelet-derived/Vascular endothelial growth factor
• PDGF/VEGF domain
• CXCXC repeat

KeywordsUniProt

• Angiogenesis
• Cleavage on pair of basic residues
• Developmental protein
• Differentiation
• Disulfide bond
• Glycoprotein
• Growth factor
• Mitogen
• Repeat
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of VEGFD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FLT4